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Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

验证数据展示

  • WB analysis using 68264-1-Ig (same clone as 68264-1-PBS)

    WB analysis using 68264-1-Ig (same clone as 68264-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 68264-1-Ig (TMPRSS2 antibody) at dilution of 1:4000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68264-1-PBS in a different storage buffer formulation.

  • WB analysis using 68264-1-Ig (same clone as 68264-1-PBS)

    WB analysis using 68264-1-Ig (same clone as 68264-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 68264-1-Ig (TMPRSS2 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. The membrane was stripped and reblotted with HRP-conjugated GAPDH Monoclonal antibody (HRP-60004) as loading control. This data was developed using the same antibody clone with 68264-1-PBS in a different storage buffer formulation.

  • WB analysis of pig kidney using 68264-1-Ig (same clone as 68264-1-PBS)

    WB analysis of pig kidney using 68264-1-Ig (same clone as 68264-1-PBS)

    pig kidney tissue were subjected to SDS PAGE followed by western blot with 68264-1-Ig (TMPRSS2 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68264-1-PBS in a different storage buffer formulation.

TMPRSS2 Monoclonal antibody, PBS Only

TMPRSS2 Monoclonal Antibody for WB, Indirect ELISA
Cat No. 68264-1-PBS

产品说明书

CloneNo. 1H7E9

宿主/亚型

Mouse / IgG1

种属反应性

Human, Pig

应用

WB, Indirect ELISA

别名

FLJ41954, PP9284, PRSS10, Serine protease 10, TMPRSS2

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

68264-1-PBS targets TMPRSS2 in WB, Indirect ELISA applications and shows reactivity with Human, Pig samples.

经测试应用 WB, Indirect ELISA Application Description
经测试反应性 Human, Pig
免疫原 TMPRSS2 fusion protein Ag5824 种属同源性预测
宿主/亚型 Mouse / IgG1
抗体类别 Monoclonal
产品类型 Antibody
全称 transmembrane protease, serine 2
别名 FLJ41954, PP9284, PRSS10, Serine protease 10, TMPRSS2
计算分子量 54 kDa
观测分子量50 kDa
GenBank蛋白编号BC051839
基因名称 TMPRSS2
Gene ID (NCBI) 7113
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein G purification
UNIPROT IDO15393
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

TMPRSS2, also named as PRSS10, is a type II transmembrane serine protease which is highly expressed by the epithelium of the human prostate gland. TMPRSS2 may contribute to prostate tumour metastasis via the activation of PAR-2. TMPRSS2 is a Serine protease that proteolytically cleaves and activates the viral spike glycoproteins which facilitate virus-cell membrane fusions. TMPRSS2 is a host cell factor that is critical for the spread of several clinically relevant viruses, including influenza A viruses and coronaviruses (PMID: 23468491, 30626688). SARS-CoV-2 uses the SARS-CoV receptor ACE2 for entry and the serine protease TMPRSS2 for S protein priming. The initial spike protein priming by TMPRSS2 is essential for the entry and viral spread of SARS-CoV-2 through interaction with the ACE2 receptor (PMID: 32142651, 30626688 ). Camostat mesylate, an inhibitor of TMPRSS2, can block SARS-CoV-2 infection of lung cells (PMID: 32142651). The MW of TMPRSS2 is about 65-70 kDa. It can be cleaved into some chains with MW 54 kDa, 31 kDa and 26 kDa (PMID: 25734995, 20382709, 26018085).