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CoraLite®555-conjugated TNF Alpha Monoclonal antibody

TNF Alpha Monoclonal Antibody for

Host / Isotype

Mouse / IgG1

Reactivity

Human

Applications

Conjugate

CoraLite®555 Fluorescent Dye

CloneNo.

11H8A5

Cat no : CL555-69002

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Synonyms

Cachectin, DIF, NeutraKine® TNF Alpha, TNF, TNF a, TNF alpha, TNFA, TNF-alpha, TNFSF2, Tumor necrosis factor

验证数据展示

Planning an IHC experiment? We recommend our IHCeasy TNF Ready-To-Use IHC Kit. TNF primary antibody included.
For other applications, we recommend the unconjugated version of this antibody, 69002-1-Ig

产品信息

CL555-69002 targets TNF Alpha in applications and shows reactivity with Human samples.

Tested Applications Application Description
Tested Reactivity Human
Immunogen TNF Alpha fusion protein HZ-1014 种属同源性预测
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Full Name tumor necrosis factor (TNF superfamily, member 2)
Synonyms Cachectin, DIF, NeutraKine® TNF Alpha, TNF, TNF a, TNF alpha, TNFA, TNF-alpha, TNFSF2, Tumor necrosis factor
Gene Symbol TNF-alpha
Gene ID (NCBI) 7124
ENSEMBL Gene IDENSG00000232810
Conjugate CoraLite®555 Fluorescent Dye
Excitation/Emission Maxima Wavelengths557 nm / 570 nm
Form Liquid
Purification MethodProtein G purification
Storage Buffer PBS with 50% Glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3.
Storage ConditionsStore at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

TNF, as also known as TNF-alpha, or cachectin, is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. It is expressed as a 26 kDa membrane bound protein and is then cleaved by TNF-alpha converting enzyme (TACE) to release the soluble 17 kDa monomer, which forms homotrimers in circulation. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, INS resistance, and cancer.

This antibody can be used to neutralize the bioactivity of TNF alpha.