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TPX2 Monoclonal antibody, PBS Only

TPX2 Monoclonal Antibody for WB,Indirect ELISA

Host / Isotype

Mouse / IgG2b

Reactivity

Human, mouse, rat

Applications

WB,Indirect ELISA

Conjugate

Unconjugated

CloneNo.

2E10C1

Cat No : 68712-1-PBS

Print datasheet

Synonyms

C20orf1, C20orf2, DIL 2, DIL2, FLS353, GD:C20orf1, HCA519, HCTP4, p100, Protein fls353, REPP86, Targeting protein for Xklp2, TPX2

验证数据展示

  • WB analysis using 68712-1-Ig (same clone as 68712-1-PBS)

    WB analysis using 68712-1-Ig (same clone as 68712-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 68712-1-Ig (TPX2 antibody) at dilution of 1:20000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68712-1-PBS in a different storage buffer formulation.

  • WB analysis using 68712-1-Ig (same clone as 68712-1-PBS)

    WB analysis using 68712-1-Ig (same clone as 68712-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 68712-1-Ig (TPX2 antibody) at dilution of 1:20000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68712-1-PBS in a different storage buffer formulation.

Planning an IHC experiment? We recommend our IHCeasy TPX2 Ready-To-Use IHC Kit. TPX2 primary antibody included.

产品信息

68712-1-PBS targets TPX2 in WB, Indirect ELISA applications and shows reactivity with Human, mouse, rat samples.

Tested Applications WB,Indirect ELISA Application Description
Tested Reactivity Human, mouse, rat
Immunogen TPX2 fusion protein Ag33683 种属同源性预测
Host / Isotype Mouse / IgG2b
Class Monoclonal
Type Antibody
Full Name TPX2, microtubule-associated, homolog (Xenopus laevis)
Synonyms C20orf1, C20orf2, DIL 2, DIL2, FLS353, GD:C20orf1, HCA519, HCTP4, p100, Protein fls353, REPP86, Targeting protein for Xklp2, TPX2
Calculated Molecular Weight 747 aa, 86 kDa
Observed Molecular Weight 98 kDa
GenBank Accession NumberBC020207
Gene Symbol TPX2
Gene ID (NCBI) 22974
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDQ9ULW0
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

背景介绍

TPX2, also known as DIL2, p10, is a microtubule organization- and cell cycle-associated protein. In the early stage of mitosis, TPX2 is released in a RanGTP-dependent manner and plays a significant role in mitotic spindle formation and subsequent proper segregation of chromosomes during cell division. Furthermore, during interphase, TPX2 is involved in DNA damage response by regulation of γ-H2AX signals(PMID: 25914189). Aberrant expression of TPX2 leads to improper spindle assembly and chromosomal instability. Overexpressed in cancers, TPX2 is being established as the marker for the diagnosis and prognosis of malignancies(PMID: 24556998).