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TRAF5 Monoclonal antibody, PBS Only

TRAF5 Monoclonal Antibody for WB, Indirect ELISA

Host / Isotype

Mouse / IgG1

Reactivity

Human

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

1B1A7

Cat no : 66991-1-PBS

Print datasheet

Synonyms

RING finger protein 84, RNF84, TRAF5

验证数据展示

  • WB analysis of HeLa using 66991-1-Ig (same clone as 66991-1-PBS)

    WB analysis of HeLa using 66991-1-Ig (same clone as 66991-1-PBS)

    HeLa cells were subjected to SDS PAGE followed by western blot with 66991-1-Ig (TRAF5 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66991-1-PBS in a different storage buffer formulation.

产品信息

66991-1-PBS targets TRAF5 in WB, Indirect ELISA applications and shows reactivity with Human samples.

Tested Applications WB, Indirect ELISA Application Description
Tested Reactivity Human
Immunogen TRAF5 fusion protein Ag26070 种属同源性预测
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Full Name TNF receptor-associated factor 5
Synonyms RING finger protein 84, RNF84, TRAF5
Calculated Molecular Weight 557 aa, 64 kDa
Observed Molecular Weight 64 kDa
GenBank Accession NumberBC029600
Gene Symbol TRAF5
Gene ID (NCBI) 7188
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDO00463
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

TRAF5 (also known as TNF receptor-associated factor 5, Ring finger protein 84, RNF8, MGC:39780) is a member of the tumor necrosis factor receptor-associated (TRAF) family of proteins that are characterized by the presence of a meprin and TRAF homology (MATH) domain, a RING-type zinc finger domain, and two TRAF-type zinc finger domains (https://www.uniprot.org/uniprot/O00463). TRAF5 is a scaffold protein that associates with and mediates signal transduction by cell surface receptors belonging to the tumor necrosis factor (TNF) superfamily, including CD27, CD30, CD40, and lymphotoxin-β receptor, positively regulating activation of the canonical NF-κB pathway and c-Jun NH2-terminal kinase (JNK) activation by these receptors (PMIDs: 8999898, 9582383, 8790348, 8663299). The RING-type zinc finger domain of TRAF5 exhibits ubiquitin protein ligase activity and is responsible for Lys-63-linked polyubiquitination of protein targets (PMIDs:23758787, 29176576). This domain has been demonstrated to be required for TRAF5-mediated activation of NF-κB (PMID:8663299).