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TREK1/KCNK2 Polyclonal antibody, PBS Only

TREK1/KCNK2 Polyclonal Antibody for WB, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

Cat no : 26807-1-PBS

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Synonyms

验证数据展示

  • WB analysis using 26807-1-AP (same clone as 26807-1-PBS)

    WB analysis using 26807-1-AP (same clone as 26807-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 26807-1-AP (TREK1 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 26807-1-PBS in a different storage buffer formulation.

产品信息

26807-1-PBS targets TREK1/KCNK2 in WB, Indirect ELISA applications and shows reactivity with human samples.

Tested Applications WB, Indirect ELISA Application Description
Tested Reactivity human
Immunogen TREK1/KCNK2 fusion protein Ag25209 种属同源性预测
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Full Name potassium channel, subfamily K, member 2
Synonyms
Calculated Molecular Weight 411 aa, 46 kDa
Observed Molecular Weight40-50 kDa
GenBank Accession NumberBC101693
Gene Symbol TREK1
Gene ID (NCBI) 3776
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDO95069
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

The tandem of pore domains in a weak inward rectifying K+ channel (TWIK1, K2P1.1, or KCNK1) and TWIK-related K+channel 1 (TREK1, K2P 2.1, or KCNK2) are members of the two pore domain potassium (K2P) channel family, consisting of 15 channels that regulate the stabilization of resting membrane potential and cellular excitability by wielding background K+ leakage currents (PMID:12580339). TREK1/KCNK2 is sensitive to a wide range of physical and chemical cues. Its main role is to maintain the resting potential of the cell and whilst highly expressed in the nervous system, TREK1/KCNK2 is also expressed in the kidney, heart, lung and smooth muscle cells (PMID:31031627).