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TTBK2 Recombinant antibody, PBS Only

TTBK2 Uni-rAbTM Recombinant Antibody for WB, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

241456B4

Cat no : 84634-1-PBS

Print datasheet

Synonyms

Tau-tubulin kinase 2, tau tubulin kinase 2, SCA11, KIAA0847, EC:2.7.11.1

验证数据展示

  • WB analysis using 84634-1-RR (same clone as 84634-1-PBS)

    WB analysis using 84634-1-RR (same clone as 84634-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 84634-1-RR (TTBK2 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84634-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 84634-1-RR

    Affinity and Kinetic Characterization of 84634-1-RR

    Biolayer interferometry (BLl) kinetic assays of 84634-1-RR against Human TTBK2 were performed. The affinity constant is 0.14 nM.

Planning an IHC experiment? We recommend our IHCeasy TTBK2 Ready-To-Use IHC Kit. TTBK2 primary antibody included.

产品信息

84634-1-PBS targets TTBK2 in WB, Indirect ELISA applications and shows reactivity with human samples.

Tested Applications WB, Indirect ELISA Application Description
Tested Reactivity human
Immunogen TTBK2 fusion protein Ag7108 种属同源性预测
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Full Name tau tubulin kinase 2
Synonyms Tau-tubulin kinase 2, tau tubulin kinase 2, SCA11, KIAA0847, EC:2.7.11.1
Calculated Molecular Weight 137 kDa
Observed Molecular Weight 137-150 kDa
GenBank Accession NumberBC071556
Gene Symbol TTBK2
Gene ID (NCBI) 146057
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
UNIPROT IDQ6IQ55
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

TTBK2(tau tubulin kinase 2) plays an important role in the tau cascade and in spinocerebellar degeneration. The N-terminus of TTBK2 has a serine-threonine-tyrosine kinase domain, and a C-terminal region shows homology to TTBK1. TTBK1 and TTBK2 function as regulators of TDP-43 phosphorylation. TTBK1/2 may be attractive drug targets for therapeutic interventions in TDP-43 proteinopathies such as FTLD-TDP and ALS.(PMID:25473830).