验证数据展示
经过测试的应用
| Positive WB detected in | PC-3 cells, HepG2 cells, L02 cells |
Planning an IHC experiment? We recommend our IHCeasy TTBK2 Ready-To-Use IHC Kit. TTBK2 primary antibody included.
推荐稀释比
| 应用 | 推荐稀释比 |
|---|---|
| Western Blot (WB) | WB : 1:5000-1:50000 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
产品信息
84634-1-RR targets TTBK2 in WB, ELISA applications and shows reactivity with human samples.
| 经测试应用 | WB, ELISA Application Description |
| 经测试反应性 | human |
| 免疫原 | TTBK2 fusion protein Ag7108 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Recombinant |
| 产品类型 | Antibody |
| 全称 | tau tubulin kinase 2 |
| 别名 | Tau-tubulin kinase 2, tau tubulin kinase 2, SCA11, KIAA0847, EC:2.7.11.1 |
| 计算分子量 | 137 kDa |
| 观测分子量 | 137-150 kDa |
| GenBank蛋白编号 | BC071556 |
| 基因名称 | TTBK2 |
| Gene ID (NCBI) | 146057 |
| RRID | AB_3672094 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein A purfication |
| UNIPROT ID | Q6IQ55 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol , pH 7.3 |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
TTBK2(tau tubulin kinase 2) plays an important role in the tau cascade and in spinocerebellar degeneration. The N-terminus of TTBK2 has a serine-threonine-tyrosine kinase domain, and a C-terminal region shows homology to TTBK1. TTBK1 and TTBK2 function as regulators of TDP-43 phosphorylation. TTBK1/2 may be attractive drug targets for therapeutic interventions in TDP-43 proteinopathies such as FTLD-TDP and ALS.(PMID:25473830).
实验方案
| Product Specific Protocols | |
|---|---|
| WB protocol for TTBK2 antibody 84634-1-RR | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |