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Host
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Species Reactivity
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Species Reactivity
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Conjugate
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Conjugate
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验证数据展示

  • WB analysis using 83416-4-RR (same clone as 83416-4-PBS)

    WB analysis using 83416-4-RR (same clone as 83416-4-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 83416-4-RR (Thrombomodulin antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 83416-4-PBS in a different storage buffer formulation.

  • IHC staining of human lung using 83416-4-RR (same clone as 83416-4-PBS)

    IHC staining of human lung using 83416-4-RR (same clone as 83416-4-PBS)

    Immunohistochemical analysis of paraffin-embedded human lung tissue slide using 83416-4-RR (Thrombomodulin antibody) at dilution of 1:1000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 83416-4-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with CD141/Thrombomodulin antibody included
  • IHC staining of human lung using 83416-4-RR (same clone as 83416-4-PBS)

    IHC staining of human lung using 83416-4-RR (same clone as 83416-4-PBS)

    Immunohistochemical analysis of paraffin-embedded human lung tissue slide using 83416-4-RR (Thrombomodulin antibody) at dilution of 1:1000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 83416-4-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with CD141/Thrombomodulin antibody included
  • IF Staining of A431 using 83416-4-RR (same clone as 83416-4-PBS)

    IF Staining of A431 using 83416-4-RR (same clone as 83416-4-PBS)

    Immunofluorescent analysis of (4% PFA) fixed A431 cells using Thrombomodulin antibody (83416-4-RR, Clone: 240365D1 ) at dilution of 1:250 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L) (SA00013-2). This data was developed using the same antibody clone with 83416-4-PBS in a different storage buffer formulation.

  • IHC staining of human placenta using 83416-4-RR (same clone as 83416-4-PBS)

    IHC staining of human placenta using 83416-4-RR (same clone as 83416-4-PBS)

    Immunohistochemical analysis of paraffin-embedded human placenta tissue slide using 83416-4-RR (CD141/Thrombomodulin antibody) at dilution of 1:4000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 83416-4-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with CD141/Thrombomodulin antibody included
  • Affinity and Kinetic Characterization of 83416-4-RR

    Affinity and Kinetic Characterization of 83416-4-RR

    Biolayer interferometry (BLl) kinetic assays of 83416-4-RR against Human CD141/Thrombomodulin were performed. The affinity constant is 1.15 nM.

CD141/Thrombomodulin Recombinant antibody, PBS Only

CD141/Thrombomodulin Uni-rAbTM Recombinant Antibody for WB, IHC, IF/ICC, ELISA
Cat No. 83416-4-PBS

产品说明书

CloneNo. 240365D1

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, IHC, IF/ICC, ELISA

别名

THBD, Thrombomodulin, THRM, Fetomodulin, CD141

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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Planning an IHC experiment? We recommend our IHCeasy CD141/Thrombomodulin Ready-To-Use IHC Kit. CD141/Thrombomodulin primary antibody included.

产品信息

83416-4-PBS targets CD141/Thrombomodulin in WB, IHC, IF/ICC, ELISA applications and shows reactivity with human samples.

经测试应用 WB, IHC, IF/ICC, ELISA Application Description
经测试反应性 human
免疫原 Recombinant protein 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 thrombomodulin
别名 THBD, Thrombomodulin, THRM, Fetomodulin, CD141
计算分子量60 kDa
观测分子量 100-105 kDa
GenBank蛋白编号NM_000361.3
基因名称 THBD
Gene ID (NCBI) 7056
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purfication
UNIPROT IDP07204
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Thrombomodulin, also known as CD141, is an endothelial cell surface glycoprotein that forms a 1:1 complex with the coagulation factor thrombin and plays an important role as a natural anticoagulant. Thrombomodulin serves to convert thrombin from a procoagulant protein into the activator for protein C. Once converted to activated protein C (APC), this protein serves as a major anticoagulant in blood (PMID: 2827310). Thrombomodulin is also located in other cells (keratinocytes, osteoblasts, macrophages,...) where it might be involved in cell differentiation or in inflammation (PMID: 9814688). In humans, thrombomodulin is encoded by the THBD gene. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia. Thrombomodulin is glycosylated and has an apparent molecular weight of 75 to 110 kDa (PMID: 1650405; 2827310).