验证数据展示
产品信息
66937-1-PBS targets UBR5 in WB, IHC, Indirect ELISA applications and shows reactivity with Human, mouse, rat samples.
Tested Applications | WB, IHC, Indirect ELISA Application Description |
Tested Reactivity | Human, mouse, rat |
Immunogen | UBR5 fusion protein Ag18753 种属同源性预测 |
Host / Isotype | Mouse / IgG1 |
Class | Monoclonal |
Type | Antibody |
Full Name | ubiquitin protein ligase E3 component n-recognin 5 |
Synonyms | DD5, EDD, EDD1, FLJ11310, hHYD, HYD, KIAA0896, Progestin induced protein, UBR5 |
Calculated Molecular Weight | 2799 aa, 309 kDa |
Observed Molecular Weight | 309 kDa |
GenBank Accession Number | BC137234 |
Gene Symbol | UBR5 |
Gene ID (NCBI) | 51366 |
RRID | AB_2882261 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein G purification |
UNIPROT ID | O95071 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
UBR5, also named as ubiquitin protein ligase E3 component n-reconin5, is a HECT domain-containing protein as a myocardin-binding protein. UBR5 is highly conserved in metazoans, has unique structural features, and has been implicated in regulation of DNA damage response, metabolism, transcription, and apoptosis. Hence, UBR5 is a key regulator of cell signaling relevant to broad areas of cancer biology (PMID: 26464214). The human UBR5 gene has 59 exons, encoding an approximately 10kb mRNA and >300 kDa protein with widespread expression in various cell types.