验证数据展示
产品信息
68445-1-PBS targets ULK1 in WB, IHC, Indirect ELISA applications and shows reactivity with Human, Mouse, Rat samples.
经测试应用 | WB, IHC, Indirect ELISA Application Description |
经测试反应性 | Human, Mouse, Rat |
免疫原 | ULK1 fusion protein Ag22397 种属同源性预测 |
宿主/亚型 | Mouse / IgG1 |
抗体类别 | Monoclonal |
产品类型 | Antibody |
全称 | unc-51-like kinase 1 (C. elegans) |
别名 | ATG1, FLJ38455, FLJ46475, KIAA0722, ULK1, Unc 51 like kinase 1, UNC51, Unc51.1 |
观测分子量 | 130-150 kDa |
GenBank蛋白编号 | NM_003565 |
基因名称 | ULK1 |
Gene ID (NCBI) | 8408 |
偶联类型 | Unconjugated |
形式 | Liquid |
纯化方式 | Protein G purification |
UNIPROT ID | O75385 |
储存缓冲液 | PBS only , pH 7.3 |
储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
ULK1, also named as KIAA0722, belongs to the protein kinase superfamily, Ser/Thr protein kinase family and APG1/unc-51/ULK1 subfamily. It is involved in autophagy. ULK1 is required for autophagosome formation. It forms a stable complex with Atg13 and focal adhesion kinase (FAK) family interacting protein of 200 kDa (FIP 200)(PMID:21460634). ULK1 phosphorylates ATG13/KIAA0652. It is involved in axon growth. ULK1 plays an essential role in neurite extension of cerebellar granule cells. ULK1 represents a potential novel prognostic biomarker for HCC patients and may play an important role during the progression of HCC(PMID:23573318).