验证数据展示
产品信息
68445-1-PBS targets ULK1 in WB, IHC, Indirect ELISA applications and shows reactivity with Human, Mouse, Rat samples.
Tested Applications | WB, IHC, Indirect ELISA Application Description |
Tested Reactivity | Human, Mouse, Rat |
Immunogen | ULK1 fusion protein Ag22397 种属同源性预测 |
Host / Isotype | Mouse / IgG1 |
Class | Monoclonal |
Type | Antibody |
Full Name | unc-51-like kinase 1 (C. elegans) |
Synonyms | ATG1, FLJ38455, FLJ46475, KIAA0722, ULK1, Unc 51 like kinase 1, UNC51, Unc51.1 |
Observed Molecular Weight | 130-150 kDa |
GenBank Accession Number | NM_003565 |
Gene Symbol | ULK1 |
Gene ID (NCBI) | 8408 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein G purification |
UNIPROT ID | O75385 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
ULK1, also named as KIAA0722, belongs to the protein kinase superfamily, Ser/Thr protein kinase family and APG1/unc-51/ULK1 subfamily. It is involved in autophagy. ULK1 is required for autophagosome formation. It forms a stable complex with Atg13 and focal adhesion kinase (FAK) family interacting protein of 200 kDa (FIP 200)(PMID:21460634). ULK1 phosphorylates ATG13/KIAA0652. It is involved in axon growth. ULK1 plays an essential role in neurite extension of cerebellar granule cells. ULK1 represents a potential novel prognostic biomarker for HCC patients and may play an important role during the progression of HCC(PMID:23573318).