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验证数据展示

  • WB analysis using 28384-1-AP (same clone as 28384-1-PBS)

    WB analysis using 28384-1-AP (same clone as 28384-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 28384-1-AP (UPF1 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 28384-1-PBS in a different storage buffer formulation.

  • WB analysis of HEK-293 using 28384-1-AP (same clone as 28384-1-PBS)

    WB analysis of HEK-293 using 28384-1-AP (same clone as 28384-1-PBS)

    WB result of UPF1 antibody (28384-1-AP; 1:10000; incubated at room temperature for 1.5 hours) with sh-Control and sh-UPF1 transfected HEK-293 cells. This data was developed using the same antibody clone with 28384-1-PBS in a different storage buffer formulation.

  • IHC staining of human breast cancer using 28384-1-AP (same clone as 28384-1-PBS)

    IHC staining of human breast cancer using 28384-1-AP (same clone as 28384-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 28384-1-AP (UPF1 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 28384-1-PBS in a different storage buffer formulation.

  • IHC staining of human breast cancer using 28384-1-AP (same clone as 28384-1-PBS)

    IHC staining of human breast cancer using 28384-1-AP (same clone as 28384-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 28384-1-AP (UPF1 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 28384-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO验证

UPF1 Polyclonal antibody, PBS Only

UPF1 Polyclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 28384-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, IHC, Indirect ELISA

别名

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

28384-1-PBS targets UPF1 in WB, IHC, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human
免疫原 UPF1 fusion protein Ag29057 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 UPF1 regulator of nonsense transcripts homolog (yeast)
别名
计算分子量123 kDa
观测分子量 123-130 kDa
GenBank蛋白编号BC039817
基因名称 UPF1
Gene ID (NCBI) 5976
RRIDAB_2881130
偶联类型 Unconjugated
形式 Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ92900
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Up-Frameshift Suppressor 1 Homolog (UPF1) is the central factor in nonsense-mediated mRNA decay (NMD) and is also directly involved in telomere homeostasis, DNA replication, histone mRNA degradation and staufen-mediated mRNA decay (PMID: 29382845). It is a potential modulator of MALAT1 and that UPF1/MALAT1 pathway could be a therapeutic target for gastric cancer (PMID: 28942451). The molecular mass of UPF1 is 123-130 kDa.