验证数据展示
产品信息
67917-1-PBS targets USP10 in WB, IHC, IF/ICC, Indirect ELISA applications and shows reactivity with Human, mouse, rat samples.
Tested Applications | WB, IHC, IF/ICC, Indirect ELISA Application Description |
Tested Reactivity | Human, mouse, rat |
Immunogen | USP10 fusion protein Ag7233 种属同源性预测 |
Host / Isotype | Mouse / IgG1 |
Class | Monoclonal |
Type | Antibody |
Full Name | ubiquitin specific peptidase 10 |
Synonyms | Deubiquitinating enzyme 10, KIAA0190, Ubiquitin thiolesterase 10, UBPO, USP10 |
Calculated Molecular Weight | 87 kDa, 92 kDa |
Observed Molecular Weight | 100-110 kDa |
GenBank Accession Number | BC000263 |
Gene Symbol | USP10 |
Gene ID (NCBI) | 9100 |
RRID | AB_2918671 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
UNIPROT ID | Q14694 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
USP10, a cytoplasmic ubiquitin-specific protease, deubiquitinates p53, reversing Mdm2-induced p53 nuclear export and degradation. After DNA damage, USP10 is stabilized, and a fraction of USP10 translocates to the nucleus to activate p53. The translocation and stabilization of USP10 is regulated by ATM -mediated phosphorylation of USP10 at Thr42 and Ser337. (PMID: 20096447, PMID: 26876938)