VE-cadherin/CD144 Recombinant antibody, PBS Only

VE-cadherin/CD144 Uni-rAbTM Recombinant Antibody for WB, IF-P, Indirect ELISA
Cat No. 83766-6-PBS

产品说明书

CloneNo. 240755D5

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, IF-P, Indirect ELISA

VE-cadherin, CDH5, CD144, Cadherin 5, 7B4 antigen

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -


产品信息

83766-6-PBS targets VE-cadherin/CD144 in WB, IF-P, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, IF-P, Indirect ELISA Application Description
经测试反应性 human
免疫原 VE-cadherin/CD144 fusion protein Eg1200 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 cadherin 5, type 2 (vascular endothelium)
别名 VE-cadherin, CDH5, CD144, Cadherin 5, 7B4 antigen
计算分子量88 kDa
观测分子量90-100 kDa, 130-140 kDa
GenBank蛋白编号NM_001795.5
基因名称 VE-cadherin
Gene ID (NCBI) 1003
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purfication
UNIPROT IDP33151-1
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Cadherins are a family of transmembrane glycoproteins that mediate calcium-dependent cell-cell adhesion and play an important role in the maintenance of normal tissue architecture. Vascular endothelial cadherin (VE-cadherin), also known as Cadherin-5 (CDH5) or CD144, is a member of the type II classical cadherin family of cell adhesion proteins (PMID: 21269602). VE-cadherin is expressed specifically in endothelial cells and mediates homophilic adhesion in the vascular endothelium (PMID: 1522121; 8555485; 21269602). VE-cadherin plays a role in the organization of lateral endothelial junctions and in the control of permeability properties of vascular endothelium (PMID: 1522121). VE-cadherin has also been shown to be required for angiogenesis (PMID: 16473763; 18162609). The calculated molecular weight of VE-cadherin is 88 kDa and the apparent molecular weight of 120-140 kDa is higher due to post-translational glycosylation and phosphorylation (PMID: 10460833; 29894844). Full-length VE-cadherin can be proteolytically cleaved to generate a fragment of 90-100 kDa (PMID: 9786462; 22064597).

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