验证数据展示
产品信息
67937-1-PBS targets WDR1 in WB, Indirect ELISA applications and shows reactivity with human, rat samples.
| Tested Applications | WB, Indirect ELISA Application Description |
| Tested Reactivity | human, rat |
| Immunogen | WDR1 fusion protein Ag30967 种属同源性预测 |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Full Name | WD repeat domain 1 |
| Synonyms | WD repeat containing protein 1, NORI-1, NORI 1, AIP1, Actin-interacting protein 1 |
| Calculated Molecular Weight | 606 aa, 66 kDa |
| Observed Molecular Weight | 65-66 kDa |
| GenBank Accession Number | BC030541 |
| Gene Symbol | WDR1 |
| Gene ID (NCBI) | 9948 |
| RRID | AB_2918689 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Protein G purification |
| UNIPROT ID | O75083 |
| Storage Buffer | PBS Only |
| Storage Conditions | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
WDR1, which belongs to the WD repeat AIP1 family, also known as AIP1, is a 606 amino acid protein that localizes to the cytoskeleton. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, mostly including a trp-asp at the C-terminal end. WDR1 induces the disassembly of actin filaments in conjunction with ADF/cofilin family proteins (PMID:15629458, 27557945, 29751004). WDR1 mutations may impair the ability of WDR1 to regulate cofilin-mediated actin depolymerization, and are associated with periodic fever, immunodeficiency, and thrombocytopenia syndrome (PMID: 27557945,27994071,29751004).
