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Host
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Conjugate
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验证数据展示

  • WB analysis of HEK-293 using 67463-1-Ig (same clone as 67463-1-PBS)

    WB analysis of HEK-293 using 67463-1-Ig (same clone as 67463-1-PBS)

    HEK-293 cells were subjected to SDS PAGE followed by western blot with 67463-1-Ig (ZNF746 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67463-1-PBS in a different storage buffer formulation.

ZNF746 Monoclonal antibody, PBS Only

ZNF746 Monoclonal Antibody for WB, Indirect ELISA
Cat No. 67463-1-PBS

产品说明书

CloneNo. 3A12C5

宿主/亚型

Mouse / IgG1

种属反应性

Human

应用

WB, Indirect ELISA

别名

FLJ31413, PARIS, zinc finger protein 746, ZNF746

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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Planning an IHC experiment? We recommend our IHCeasy ZNF746 Ready-To-Use IHC Kit. ZNF746 primary antibody included.

产品信息

67463-1-PBS targets ZNF746 in WB, Indirect ELISA applications and shows reactivity with Human samples.

经测试应用 WB, Indirect ELISA Application Description
经测试反应性 Human
免疫原 ZNF746 fusion protein Ag21582 种属同源性预测
宿主/亚型 Mouse / IgG1
抗体类别 Monoclonal
产品类型 Antibody
全称 zinc finger protein 746
别名 FLJ31413, PARIS, zinc finger protein 746, ZNF746
计算分子量 644 aa, 69 kDa
观测分子量85-90 kDa
GenBank蛋白编号BC068505
基因名称 ZNF746
Gene ID (NCBI) 155061
RRIDAB_2918491
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein G purification
UNIPROT IDQ6NUN9
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

ZNF746, also named as PARIS, which belongs to the krueppel C2H2-type zinc-finger protein family. ZNF746 mainly localizes to the cytoplasm and probably translocates to the nucleus to repress selected genes. ZNF746 as a transcription repressor that specifically binds to the 5'-TATTTT[T/G]-3' consensus sequence on promoters and repress transcription of PGC-1-alpha (PPARGC1A), thereby playing a role in regulation of neuron death. ZNF746 may act as a downstream effector of PRKN and contribute to neurodegeneration in Parkinson disease cases caused by defects in PRKN: its accumulation due to the absence of PRKN, followed by up-regulation of PPARGC1A, could lead to the selective loss of dopamine neurons in the substantia nigra(PMID: 28122242). The calculated molecular weight of ZNF746 is 69 kDa, but Phosphorylation of ZNF746 is about 80-85 kDa (PMID: 28122242).