• All
  • Primary Antibodies
  • Conjugated Antibodies for IF
  • Conjugated Antibodies for FC
  • Secondary Antibodies
  • Antibody Labeling KitsNew
  • ELISA Kits
  • IHC Kits
  • Magnetic Cell Separation Kits
  • Cytokines & Growth Factors
  • Neutralizing/activating Antibodies
  • Nanobody-based Reagents
  • Accessory Products and Kits
  • Fusion Proteins
×
×
Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

ZNF746 Monoclonal antibody, PBS Only

ZNF746 Monoclonal Antibody for WB, Indirect ELISA

Host / Isotype

Mouse / IgG1

Reactivity

Human

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

3A12C5

Cat No : 67463-1-PBS

Print datasheet

Synonyms

FLJ31413, PARIS, zinc finger protein 746, ZNF746

验证数据展示

  • WB analysis of HEK-293 using 67463-1-Ig (same clone as 67463-1-PBS)

    WB analysis of HEK-293 using 67463-1-Ig (same clone as 67463-1-PBS)

    HEK-293 cells were subjected to SDS PAGE followed by western blot with 67463-1-Ig (ZNF746 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67463-1-PBS in a different storage buffer formulation.

Planning an IHC experiment? We recommend our IHCeasy ZNF746 Ready-To-Use IHC Kit. ZNF746 primary antibody included.

产品信息

67463-1-PBS targets ZNF746 in WB, Indirect ELISA applications and shows reactivity with Human samples.

Tested Applications WB, Indirect ELISA Application Description
Tested Reactivity Human
Immunogen ZNF746 fusion protein Ag21582 种属同源性预测
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Full Name zinc finger protein 746
Synonyms FLJ31413, PARIS, zinc finger protein 746, ZNF746
Calculated Molecular Weight 644 aa, 69 kDa
Observed Molecular Weight85-90 kDa
GenBank Accession NumberBC068505
Gene Symbol ZNF746
Gene ID (NCBI) 155061
Conjugate Unconjugated
Form Liquid
Purification MethodProtein G purification
UNIPROT IDQ6NUN9
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

ZNF746, also named as PARIS, which belongs to the krueppel C2H2-type zinc-finger protein family. ZNF746 mainly localizes to the cytoplasm and probably translocates to the nucleus to repress selected genes. ZNF746 as a transcription repressor that specifically binds to the 5'-TATTTT[T/G]-3' consensus sequence on promoters and repress transcription of PGC-1-alpha (PPARGC1A), thereby playing a role in regulation of neuron death. ZNF746 may act as a downstream effector of PRKN and contribute to neurodegeneration in Parkinson disease cases caused by defects in PRKN: its accumulation due to the absence of PRKN, followed by up-regulation of PPARGC1A, could lead to the selective loss of dopamine neurons in the substantia nigra(PMID: 28122242). The calculated molecular weight of ZNF746 is 69 kDa, but Phosphorylation of ZNF746 is about 80-85 kDa (PMID: 28122242).