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验证数据展示

  • IF Staining of HepG2 using CL488-66626

    IF Staining of HepG2 using CL488-66626

    Immunofluorescent analysis of (4% PFA) fixed HepG2 cells using CoraLite® Plus 488 cIAP1 antibody (CL488-66626, Clone: 1H3F1 ) at dilution of 1:100.

CoraLite® Plus 488-conjugated cIAP1 Monoclonal antibody

cIAP1 Monoclonal Antibody for IF/ICC
Cat No. CL488-66626

产品说明书

CloneNo. 1H3F1

宿主/亚型

Mouse / IgG1

种属反应性

Human, mouse, rat, pig

应用

IF/ICC

别名

API1, BIRC2, C IAP1, cIAP1, Hiap 2, HIAP2, IAP 2, IAP homolog B, IAP2, MIHB, RING finger protein 48, RNF48

缓冲液配方:  PBS and Azide
PBS and Azide
偶联物:  CoraLite® Plus 488
规格: 

-/ -

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经过测试的应用

Positive IF/ICC detected inHepG2 cells
Planning an IHC experiment? We recommend our IHCeasy BIRC2/cIAP1 Ready-To-Use IHC Kit. BIRC2/cIAP1 primary antibody included.
For other applications, we recommend the unconjugated version of this antibody, 66626-1-Ig

推荐稀释比

应用推荐稀释比
Immunofluorescence (IF)/ICCIF/ICC : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

CL488-66626 targets cIAP1 in IF/ICC applications and shows reactivity with Human, mouse, rat, pig samples.

经测试应用 IF/ICC Application Description
经测试反应性 Human, mouse, rat, pig
免疫原 cIAP1 fusion protein Ag21398 种属同源性预测
宿主/亚型 Mouse / IgG1
抗体类别 Monoclonal
产品类型 Antibody
全称 baculoviral IAP repeat-containing 2
别名 API1, BIRC2, C IAP1, cIAP1, Hiap 2, HIAP2, IAP 2, IAP homolog B, IAP2, MIHB, RING finger protein 48, RNF48
计算分子量 618 aa, 70 kDa
GenBank蛋白编号BC016174
基因名称 cIAP1
Gene ID (NCBI) 329
RRIDAB_2919353
偶联类型 CoraLite® Plus 488 Fluorescent Dye
最大激发/发射波长493 nm / 522 nm
形式 Liquid
纯化方式Protein G purification
UNIPROT IDQ13490
储存缓冲液 PBS with 50% Glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3.
储存条件Store at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

BIRC2 (also known as cIAP1) is a member of the inhibitor of apoptosis protein (IAP) family. The inhibitor of apoptosis (IAP) proteins are a family of anti-apoptotic regulators found in viruses and metazoans. BIRC2 is a nuclear shuttling protein, whose subcellular localization is mediated by the CRM1-dependent nuclear export pathway (PMID: 15265700). The protein is regulated transcriptionally and can be inhibited by mitochondrial proteins released in the cytoplasm upon apoptotic stimuli (PMID: 15187025). BIRC2 is also believed to be a critical regulator of vascular integrity and endothelial cell survival, thereby providing an additional target pathway for the control of angiogenesis and blood vessel homeostasis during embryogenesis, regeneration and tumorigenesis (PMID: 17934460).

实验方案

Product Specific Protocols
IF protocol for CL Plus 488 cIAP1 antibody CL488-66626Download protocol
Standard Protocols
Click here to view our Standard Protocols