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CoraLite® Plus 488-conjugated cIAP1 Monoclonal antibody

cIAP1 Monoclonal Antibody for IF/ICC

Host / Isotype

Mouse / IgG1

Reactivity

Human, mouse, rat, pig

Applications

IF/ICC

Conjugate

CoraLite® Plus 488 Fluorescent Dye

CloneNo.

1H3F1

Cat no : CL488-66626

Print datasheet

Synonyms

API1, BIRC2, C IAP1, cIAP1, Hiap 2, HIAP2, IAP 2, IAP homolog B, IAP2, MIHB, RING finger protein 48, RNF48

验证数据展示

  • IF Staining of HepG2 using CL488-66626

    IF Staining of HepG2 using CL488-66626

    Immunofluorescent analysis of (4% PFA) fixed HepG2 cells using CoraLite® Plus 488 cIAP1 antibody (CL488-66626, Clone: 1H3F1 ) at dilution of 1:100.

经过测试的应用

Positive IF/ICC detected inHepG2 cells
Planning an IHC experiment? We recommend our IHCeasy BIRC2/cIAP1 Ready-To-Use IHC Kit. BIRC2/cIAP1 primary antibody included.
For other applications, we recommend the unconjugated version of this antibody, 66626-1-Ig

推荐稀释比

ApplicationDilution
Immunofluorescence (IF)/ICCIF/ICC : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

CL488-66626 targets cIAP1 in IF/ICC applications and shows reactivity with Human, mouse, rat, pig samples.

Tested Applications IF/ICC Application Description
Tested Reactivity Human, mouse, rat, pig
Immunogen cIAP1 fusion protein Ag21398 种属同源性预测
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Full Name baculoviral IAP repeat-containing 2
Synonyms API1, BIRC2, C IAP1, cIAP1, Hiap 2, HIAP2, IAP 2, IAP homolog B, IAP2, MIHB, RING finger protein 48, RNF48
Calculated Molecular Weight 618 aa, 70 kDa
GenBank Accession NumberBC016174
Gene Symbol cIAP1
Gene ID (NCBI) 329
RRIDAB_2919353
Conjugate CoraLite® Plus 488 Fluorescent Dye
Excitation/Emission Maxima Wavelengths493 nm / 522 nm
Form Liquid
Purification MethodProtein G purification
UNIPROT IDQ13490
Storage Buffer PBS with 50% Glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3.
Storage ConditionsStore at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

BIRC2 (also known as cIAP1) is a member of the inhibitor of apoptosis protein (IAP) family. The inhibitor of apoptosis (IAP) proteins are a family of anti-apoptotic regulators found in viruses and metazoans. BIRC2 is a nuclear shuttling protein, whose subcellular localization is mediated by the CRM1-dependent nuclear export pathway (PMID: 15265700). The protein is regulated transcriptionally and can be inhibited by mitochondrial proteins released in the cytoplasm upon apoptotic stimuli (PMID: 15187025). BIRC2 is also believed to be a critical regulator of vascular integrity and endothelial cell survival, thereby providing an additional target pathway for the control of angiogenesis and blood vessel homeostasis during embryogenesis, regeneration and tumorigenesis (PMID: 17934460).

实验方案

Product Specific Protocols
IF protocol for CL Plus 488 cIAP1 antibody CL488-66626Download protocol
Standard Protocols
Click here to view our Standard Protocols