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Host
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Species Reactivity
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Species Reactivity
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Conjugate
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Compatible Species
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Conjugate
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验证数据展示

  • WB analysis using 67766-1-Ig (same clone as 67766-1-PBS)

    WB analysis using 67766-1-Ig (same clone as 67766-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 67766-1-Ig (gp130 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67766-1-PBS in a different storage buffer formulation.

  • IHC staining of human placenta using 67766-1-Ig (same clone as 67766-1-PBS)

    IHC staining of human placenta using 67766-1-Ig (same clone as 67766-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human placenta tissue slide using 67766-1-Ig (gp130 antibody) at dilution of 1:1000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 67766-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with IL6ST/GP130 antibody included
  • IHC staining of human placenta using 67766-1-Ig (same clone as 67766-1-PBS)

    IHC staining of human placenta using 67766-1-Ig (same clone as 67766-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human placenta tissue slide using 67766-1-Ig (gp130 antibody) at dilution of 1:1000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 67766-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with IL6ST/GP130 antibody included

gp130/IL6ST Monoclonal antibody, PBS Only

gp130/IL6ST Monoclonal Antibody for WB, IHC, ELISA
Cat No. 67766-1-PBS

产品说明书

CloneNo. 1H7C5

宿主/亚型

Mouse / IgG1

种属反应性

human

应用

WB, IHC, ELISA

别名

IL6ST, IL 6 receptor subunit beta, GP130 RAPS, GP130, Glycoprotein 130

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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Planning an IHC experiment? We recommend our IHCeasy IL6ST/GP130 Ready-To-Use IHC Kit. IL6ST/GP130 primary antibody included.

产品信息

67766-1-PBS targets gp130/IL6ST in WB, IHC, ELISA applications and shows reactivity with human samples.

经测试应用 WB, IHC, ELISA Application Description
经测试反应性 human
免疫原 gp130/IL6ST fusion protein Ag28808 种属同源性预测
宿主/亚型 Mouse / IgG1
抗体类别 Monoclonal
产品类型 Antibody
全称 interleukin 6 signal transducer (gp130, oncostatin M receptor)
别名 IL6ST, IL 6 receptor subunit beta, GP130 RAPS, GP130, Glycoprotein 130
计算分子量 104 kDa
观测分子量130-140 kDa
GenBank蛋白编号NM_002184
基因名称 IL6ST
Gene ID (NCBI) 3572
RRIDAB_2918533
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purification
UNIPROT IDP40189
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Glycoprotein 130 (gp130, also known as IL6ST, CD130 or IL6-beta) is a ubiquitously expressed, signal-transducing receptor that serves as the signal transduction unit for IL-6 family of cytokines, including IL-6, IL-11, IL-27, leukemia inhibitory factor (LIF), OSM, ciliary neurotrophic factor (CNTF), cardiotrophin 1 (CT-1), and cardiotrophin-like cytokine (CLC) (PMID: 9143707; 20610800). These cytokines signal through the gp130/Jak/STAT pathway (PMID: 9716487). Binding of IL-6 to IL-6R induces gp130 homodimerization and formation of a high-affinity receptor complex, which activates Jaks. That causes phosphorylation of gp130 tyrosine residues which in turn activates STAT3. gp130 is a type I transmembrane protein, and can also exist as a soluble form (sgp130). sgp130 binds to sIL-6R/IL-6 complexes and prevents their interactions with membrane-anchored gp130 on target cells (PMID: 9815830).