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Anti-Human gp130/IL6ST Rabbit Recombinant Antibody, PBS Only

gp130/IL6ST Uni-rAbTM Recombinant Antibody for FC

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

FC

Conjugate

Unconjugated

CloneNo.

240992H1

Cat no : 98121-1-PBS

Print datasheet

Synonyms

IL6ST, IL 6 receptor subunit beta, GP130 RAPS, GP130, Glycoprotein 130

验证数据展示

  • FC experiment of human peripheral blood leukocytes using 98121-1-RR (same clone as 98121-1-PBS)

    FC experiment of human peripheral blood leukocytes using 98121-1-RR (same clone as 98121-1-PBS)

    1x10^6 human peripheral blood leukocytes were surface stained with 0.25 ug Anti-Human gp130/IL6ST Rabbit Recombinant Antibody (98121-1-RR, Clone: 240992H1) or Isotype Control, and PE-conjugated Goat Anti-Rabbit IgG. Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 98121-1-PBS in a different storage buffer formulation.

  • FC experiment of human peripheral blood leukocytes using 98121-1-RR (same clone as 98121-1-PBS)

    FC experiment of human peripheral blood leukocytes using 98121-1-RR (same clone as 98121-1-PBS)

    1x10^6 human peripheral blood leukocytes were surface stained with 0.25 ug Anti-Human gp130/IL6ST Rabbit Recombinant Antibody (98121-1-RR, Clone: 240992H1) (red) or Isotype Control (blue), and PE-conjugated Goat Anti-Rabbit IgG. Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 98121-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 98121-1-RR

    Affinity and Kinetic Characterization of 98121-1-RR

    Biolayer interferometry (BLl) kinetic assays of 98121-1-RR against Human gp130/IL6ST were performed. The affinity constant is 115 nM.

Planning an IHC experiment? We recommend our IHCeasy IL6ST/GP130 Ready-To-Use IHC Kit. IL6ST/GP130 primary antibody included.

产品信息

98121-1-PBS targets gp130/IL6ST in FC applications and shows reactivity with human samples.

Tested Applications FC Application Description
Tested Reactivity human
Immunogen Fusion Protein 种属同源性预测
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Full Name interleukin 6 signal transducer (gp130, oncostatin M receptor)
Synonyms IL6ST, IL 6 receptor subunit beta, GP130 RAPS, GP130, Glycoprotein 130
Calculated Molecular Weight 104 kDa
GenBank Accession NumberNM_002184.3
Gene Symbol IL6ST
Gene ID (NCBI) 3572
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
UNIPROT IDP40189-1
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Glycoprotein 130 (gp130, also known as IL6ST, CD130 or IL6-beta) is a ubiquitously expressed, signal-transducing receptor that serves as the signal transduction unit for IL-6 family of cytokines, including IL-6, IL-11, IL-27, leukemia inhibitory factor (LIF), OSM, ciliary neurotrophic factor (CNTF), cardiotrophin 1 (CT-1), and cardiotrophin-like cytokine (CLC) (PMID: 9143707; 20610800). These cytokines signal through the gp130/Jak/STAT pathway (PMID: 9716487). Binding of IL-6 to IL-6R induces gp130 homodimerization and formation of a high-affinity receptor complex, which activates Jaks. That causes phosphorylation of gp130 tyrosine residues which in turn activates STAT3.