Phospho-TDP43 (Ser409/410) Recombinant antibody
Phospho-TDP43 (Ser409/410) Recombinant Antibody for FC, IHC, WB, ELISA
Host / Isotype
Rabbit / IgG
Reactivity
Human, mouse and More (1)
Applications
FC, IHC, WB, ELISA and More (1)
Conjugate
Unconjugated
CloneNo.
6M10
验证数据展示
经过测试的应用
Positive WB detected in | HeLa cells |
Positive IHC detected in | frontal cortex of FTLD-TDP type B case, human brain tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
Positive FC detected in | Calyculin A treated Jurkat cells |
推荐稀释比
Application | Dilution |
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Western Blot (WB) | WB : 1:5000-1:50000 |
Immunohistochemistry (IHC) | IHC : 1:500-1:2000 |
Flow Cytometry (FC) | FC : 0.50 ug per 10^6 cells in a 100 µl suspension |
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Sample-dependent, Check data in validation data gallery. |
产品信息
80007-1-RR targets Phospho-TDP43 (Ser409/410) in WB, IHC, IF, FC, ELISA applications and shows reactivity with Human, mouse samples.
Tested Applications | FC, IHC, WB, ELISA |
Cited Applications | IF, IHC, WB |
Tested Reactivity | Human, mouse |
Cited Reactivity | human, mouse |
Immunogen | Peptide 种属同源性预测 |
Host / Isotype | Rabbit / IgG |
Class | Recombinant |
Type | Antibody |
Full Name | TAR DNA binding protein |
Synonyms | ALS10, Phospho-TDP43 (Ser409/410), TAR DNA binding protein, TAR DNA binding protein 43, TARDBP, TDP 43, TDP43, tdp-43 |
Calculated Molecular Weight | 43 kDa |
Observed Molecular Weight | 45-50 kDa |
GenBank Accession Number | NM_007375 |
Gene Symbol | TARDBP |
Gene ID (NCBI) | 23435 |
RRID | AB_2882937 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
UNIPROT ID | Q13148 |
Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
实验方案
Product Specific Protocols | |
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WB protocol for Phospho-TDP43 (Ser409/410) antibody 80007-1-RR | Download protocol |
Standard Protocols | |
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Click here to view our Standard Protocols |
发表文章
Species | Application | Title |
---|---|---|
Biochim Biophys Acta Mol Basis Dis Phosphorylated TAR DNA-Binding Protein-43: Aggregation and Antibody-Based Inhibition. | ||
bioRxiv TDP-43 pathology links innate and adaptive immunity in amyotrophic lateral sclerosis | ||
Mol Cell Neurosci Cytoplasmic TDP-43 accumulation drives changes in C-bouton number and size in a mouse model of sporadic Amyotrophic Lateral Sclerosis | ||
Front Genet Codon-optimized TDP-43 mediates neurodegeneration in a Drosophila model of ALS/FTLD | ||
NPJ Parkinsons Dis Glucocerebrosidase activity and lipid levels are related to protein pathologies in Parkinson's disease | ||
Acta Neuropathol Commun Targeting the glycine-rich domain of TDP-43 with antibodies prevents its aggregation in vitro and reduces neurofilament levels in vivo |