• HEK293 expressed
  • Endotoxin-free
  • Animal-component free

HumanKine® recombinant human IL-34 protein

Activity

2-12 ng/mL EC50

Species Reactivity

human

Purity

>95%

Cat No : HZ-1316

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Synonyms

IL34, Interleukin-34, C16orf77, MGC34647



Technical Specifications

GeneID 146433
Species Human
Expression HEK293
Activity 2-12 ng/mL EC50
Purity >95%
Endotoxin<1 EU/µg
Accession NumberQ6ZMJ4
Molecular Mass 38 kDa
Formulation 1 x PBS, See Certificate of Analysis for details
Species Reactivity human

Stability and Reconstitution

Stability and StorageProduct FormTemperature ConditionsStorage Time
(From Date of Receipt)
Lyophilized-20°C to -80°CUntil Expiry Date
LyophilizedRoom Temperature2 weeks
Reconstituted as per CofA-20°C to -80°C6 months
Reconstituted as per CofA4°C1 week
Avoid repeated freeze-thaw cycles.
Reconstitution Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile 1x PBS pH 7.4 + 0.1% HSA.

Background

IL-34 is a 6-α-helix, proinflammatory cytokine that serves as a ligand for colony-stimulating factor-1 receptor (CSF1R). It is expressed most abundantly by spleen cells. It primarily stimulates human peripheral blood monocyte proliferation and macrophage colony formation. It is also required for Langerhans cell and microglia development. IL-34 has been shown to play a protective role in cancer and Alzheimer’s disease, but it can promote the progression of several autoimmune, inflammatory, and metabolic diseases. As such IL-34 could be used as a biomarker to mark the progression of these diseases (PMID: 22579672, 27577879, 31940023).

Synonyms

IL34, Interleukin-34, C16orf77, MGC34647

Publications

SpeciesTitle

Immunity

Human microglia maturation is underpinned by specific gene regulatory networks

Authors - Claudia Z Han