• HEK293 expressed
  • Endotoxin-free
  • Animal-component free

HumanKine® recombinant human IL-34 protein



Species Reactivity




Cat No : HZ-1316

Print datasheet


IL34, Interleukin-34, C16orf77, MGC34647

Technical Specifications

GeneID 146433
Species Human
Expression HEK293
Activity Active
Purity >95%
Endotoxin<1 EU/µg
Accession NumberQ6ZMJ4
Molecular Mass 68 and 38 kDa
Formulation 50mM Acetate pH 4.5 + 75mM NaCl, See Certificate of Analysis for details
Species Reactivity human

Stability and Reconstitution

Stability and Storage Lyophilized proteins are stable for 1 year from the date of receipt if stored between (-20°C) and (-80°C). Upon reconstitution we recommend that the solution can be stored at (4°C) for short term or at (-20°C) to (-80°C) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products.
Reconstitution Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile 50mM Acetate pH 4.5.


IL-34 is a 6-α-helix, proinflammatory cytokine that serves as a ligand for colony-stimulating factor-1 receptor (CSF1R). It is expressed most abundantly by spleen cells. It primarily stimulates human peripheral blood monocyte proliferation and macrophage colony formation. It is also required for Langerhans cell and microglia development. IL-34 has been shown to play a protective role in cancer and Alzheimer’s disease, but it can promote the progression of several autoimmune, inflammatory, and metabolic diseases. As such IL-34 could be used as a biomarker to mark the progression of these diseases (PMID: 22579672, 27577879, 31940023).


IL34, Interleukin-34, C16orf77, MGC34647