- HEK293 expressed
- Endotoxin-free
- Animal-component free
HumanKine® recombinant human IL-34 protein
Activity
Active
Species Reactivity
human
Purity
>95%
Validation Data Gallery
Technical Specifications
GeneID | 146433 |
Species | Human |
Expression | HEK293 |
Activity | Active |
Purity | >95% |
Endotoxin | <1 EU/µg |
Accession Number | Q6ZMJ4 |
Molecular Mass | 68 and 38 kDa |
Formulation | 50mM Acetate pH 4.5 + 75mM NaCl, See Certificate of Analysis for details |
Species Reactivity | human |
Stability and Reconstitution
Stability and Storage | Lyophilized proteins are stable for 1 year from the date of receipt if stored between (-20°C) and (-80°C). Upon reconstitution we recommend that the solution can be stored at (4°C) for short term or at (-20°C) to (-80°C) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products. |
Reconstitution | Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile 50mM Acetate pH 4.5. |
Background
IL-34 is a 6-α-helix, proinflammatory cytokine that serves as a ligand for colony-stimulating factor-1 receptor (CSF1R). It is expressed most abundantly by spleen cells. It primarily stimulates human peripheral blood monocyte proliferation and macrophage colony formation. It is also required for Langerhans cell and microglia development. IL-34 has been shown to play a protective role in cancer and Alzheimer’s disease, but it can promote the progression of several autoimmune, inflammatory, and metabolic diseases. As such IL-34 could be used as a biomarker to mark the progression of these diseases (PMID: 22579672, 27577879, 31940023).
Synonyms
IL34, Interleukin-34, C16orf77, MGC34647