验证数据展示
产品信息
83369-6-PBS targets AHR in IHC, IF/ICC, FC (Intra), ELISA applications and shows reactivity with human samples.
Tested Applications | IHC, IF/ICC, FC (Intra), ELISA Application Description |
Tested Reactivity | human |
Immunogen | AHR fusion protein Ag12193 种属同源性预测 |
Host / Isotype | Rabbit / IgG |
Class | Recombinant |
Type | Antibody |
Full Name | aryl hydrocarbon receptor |
Synonyms | Class E basic helix-loop-helix protein 76, bHLHe76, Ah receptor, 240325G9 |
Calculated Molecular Weight | 848 aa, 96 kDa |
GenBank Accession Number | BC070080 |
Gene Symbol | AHR |
Gene ID (NCBI) | 196 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purfication |
UNIPROT ID | P35869 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that has been largely regarded as a mediator of xenobiotic metabolism (PMID:18483242). It plays a part role in physiologic activities, including attenuation of the acute phase response, cytokine signaling, T helper (TH) 17 immune cell differentiation, modulation of NF-κB activity, and regulation of hormonal signaling (PMID:20423157,18540824). It also mediates transcription factor sequestering away from a gene promoter or tethering of the AhR to a transcription factor on a promoter. AHR calculated molecular masses differ by <10%, compared with the apparent molecular masses predicted from SDS-PAGE for the two receptors (105 and 95 kDa, respectively). (PMID: 8246913)