AIM2 Monoclonal antibody, PBS Only

AIM2 Monoclonal Antibody for WB, Indirect ELISA
Cat No. 66902-3-PBS

产品说明书

CloneNo. 4C6E1

宿主/亚型

Mouse / IgG2a

种属反应性

human

应用

WB, Indirect ELISA

PYHIN4, Interferon-inducible protein AIM2, 4C6E1

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -


Planning an IHC experiment? We recommend our IHCeasy AIM2 Ready-To-Use IHC Kit. AIM2 primary antibody included.

产品信息

66902-3-PBS targets AIM2 in WB, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, Indirect ELISA Application Description
经测试反应性 human
免疫原 AIM2 fusion protein Ag14607 种属同源性预测
宿主/亚型 Mouse / IgG2a
抗体类别 Monoclonal
产品类型 Antibody
全称 absent in melanoma 2
别名 PYHIN4, Interferon-inducible protein AIM2, 4C6E1
计算分子量 343 aa, 39 kDa
观测分子量39 kDa
GenBank蛋白编号BC010940
基因名称 AIM2
Gene ID (NCBI) 9447
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purification
UNIPROT IDO14862
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Absent in melanoma 2 (AIM2) is a sensor of cytosolic DNA that is responsible for activation of the inflammasome and host immune responses to DNA viruses and intracellular bacteria [PMID:22695634]. Upon binding to DNA, it is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Otherwise, it functions as a tumor suppressor which may act by repressing NF-kappa-B transcriptional activity [PMID:16432157,20566831]. 66902-1-Ig antibody detects the 37-39 and 53 kDa protein in SDS-PAGE similar to the paper published. [PMID: 28809949]

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