验证数据展示
产品信息
84703-3-PBS targets APLP2 in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.
| Tested Applications | WB, Indirect ELISA Application Description |
| Tested Reactivity | human, mouse, rat |
| Immunogen | APLP2 fusion protein Ag6842 种属同源性预测 |
| Host / Isotype | Rabbit / IgG |
| Class | Recombinant |
| Type | Antibody |
| Full Name | amyloid beta (A4) precursor-like protein 2 |
| Synonyms | Amyloid-like protein 2, Amyloid like protein 2, Amyloid beta precursor like protein 2, Amyloid beta, A4 |
| Calculated Molecular Weight | 87 kDa |
| Observed Molecular Weight | 95-120 kDa |
| GenBank Accession Number | BC000373 |
| Gene Symbol | APLP2 |
| Gene ID (NCBI) | 334 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Protein A purfication |
| UNIPROT ID | Q06481 |
| Storage Buffer | PBS Only |
| Storage Conditions | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Amyloid precursor-like protein-2 (APLP2) is a member of the APP (amyloid precursor protein) family including APP, APLP1, and APLP2. APLP2 is ubiquitously expressed. It contains heparin-, copper- and zinc- binding domains at the N-terminus, BPTI/Kunitz inhibitor and E2 domains in the middle region, and transmembrane and intracellular domains at the C-terminus. APLP2 has been shown to regulate multiple cellular functions such as neurite outgrowth, axogenesis, corneal epithelial wound healing, cell adhesion, migration, and mitosis. The synergy of this protein and the APP is required to mediate neuromuscular transmission, spatial learning and synaptic plasticity. APLP2 has been implicated in the pathogenesis of Alzheimer's disease.