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验证数据展示

  • WB analysis of HepG2 using 66692-1-Ig (same clone as 66692-1-PBS)

    WB analysis of HepG2 using 66692-1-Ig (same clone as 66692-1-PBS)

    WB result of ASGR1 antibody (66692-1-Ig; 1:6000; incubated at room temperature for 1.5 hours) with sh-Control and sh-ASGR1 transfected HepG2 cells. This data was developed using the same antibody clone with 66692-1-PBS in a different storage buffer formulation.

  • WB analysis using 66692-1-Ig (same clone as 66692-1-PBS)

    WB analysis using 66692-1-Ig (same clone as 66692-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 66692-1-Ig (ASGR1 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66692-1-PBS in a different storage buffer formulation.

  • IHC staining of human liver using 66692-1-Ig (same clone as 66692-1-PBS)

    IHC staining of human liver using 66692-1-Ig (same clone as 66692-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human liver tissue slide using 66692-1-Ig (ASGR1 antibody) at dilution of 1:1000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 66692-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with ASGR1 antibody included
  • IHC staining of human liver using 66692-1-Ig (same clone as 66692-1-PBS)

    IHC staining of human liver using 66692-1-Ig (same clone as 66692-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human liver tissue slide using 66692-1-Ig (ASGR1 antibody) at dilution of 1:1000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 66692-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with ASGR1 antibody included
  • Featured Product
  • KD/KO验证

ASGR1 Monoclonal antibody, PBS Only

ASGR1 Monoclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 66692-1-PBS

产品说明书

CloneNo. 1G5F5

宿主/亚型

Mouse / IgG1

种属反应性

human, mouse, rat, pig

应用

WB, IHC, Indirect ELISA

别名

asialoglycoprotein receptor 1, HL-1, Asgpr1, ASGP-R 1, ASGPR 1

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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Planning an IHC experiment? We recommend our IHCeasy ASGR1 Ready-To-Use IHC Kit. ASGR1 primary antibody included.

产品信息

66692-1-PBS targets ASGR1 in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat, pig samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human, mouse, rat, pig
免疫原 ASGR1 fusion protein Ag2310 种属同源性预测
宿主/亚型 Mouse / IgG1
抗体类别 Monoclonal
产品类型 Antibody
全称 asialoglycoprotein receptor 1
别名 asialoglycoprotein receptor 1, HL-1, Asgpr1, ASGP-R 1, ASGPR 1
计算分子量 291 aa, 33 kDa
观测分子量 42-46 kDa
GenBank蛋白编号BC032130
基因名称 ASGR1
Gene ID (NCBI) 432
RRIDAB_2882046
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein G purification
UNIPROT IDP07306
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Asialoglycoprotein receptor (ASGPR), also known as the hepatic galactose/N-acetylglucosamine (GlcNAc) receptor or Ashwell receptor, is a C-type lectin expressed exclusively in hepatic parenchymal cells. ASGPR consists of two subunits, a major subunit (ASGR1, HL-1) and a minor subunit (ASGR2, HL-2), and specifically recognizes terminal β-linked galactose or GlcNAc on circulating glycoproteins or cells. This receptor plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins that contain terminal galactose or GlcNAc residues. ASGPR may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery.