验证数据展示
产品信息
66692-1-PBS targets ASGR1 in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat, pig samples.
Tested Applications | WB, IHC, Indirect ELISA Application Description |
Tested Reactivity | human, mouse, rat, pig |
Immunogen | ASGR1 fusion protein Ag2310 种属同源性预测 |
Host / Isotype | Mouse / IgG1 |
Class | Monoclonal |
Type | Antibody |
Full Name | asialoglycoprotein receptor 1 |
Synonyms | asialoglycoprotein receptor 1, HL-1, Asgpr1, ASGP-R 1, ASGPR 1 |
Calculated Molecular Weight | 291 aa, 33 kDa |
Observed Molecular Weight | 42-46 kDa |
GenBank Accession Number | BC032130 |
Gene Symbol | ASGR1 |
Gene ID (NCBI) | 432 |
RRID | AB_2882046 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein G purification |
UNIPROT ID | P07306 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Asialoglycoprotein receptor (ASGPR), also known as the hepatic galactose/N-acetylglucosamine (GlcNAc) receptor or Ashwell receptor, is a C-type lectin expressed exclusively in hepatic parenchymal cells. ASGPR consists of two subunits, a major subunit (ASGR1, HL-1) and a minor subunit (ASGR2, HL-2), and specifically recognizes terminal β-linked galactose or GlcNAc on circulating glycoproteins or cells. This receptor plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins that contain terminal galactose or GlcNAc residues. ASGPR may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery.