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验证数据展示

  • WB analysis using 85089-1-RR (same clone as 85089-1-PBS)

    WB analysis using 85089-1-RR (same clone as 85089-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 85089-1-RR (ASIC1 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85089-1-PBS in a different storage buffer formulation.

  • WB analysis using 85089-1-RR (same clone as 85089-1-PBS)

    WB analysis using 85089-1-RR (same clone as 85089-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 85089-1-RR (ASIC1 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85089-1-PBS in a different storage buffer formulation.

  • Cytometric bead array standard curve of MP01789-2

    Cytometric bead array standard curve of MP01789-2

    Cytometric bead array standard curve of MP01789-2, ASIC1 Recombinant Matched Antibody Pair, PBS Only. Capture antibody: 85089-1-PBS. Detection antibody: 85089-2-PBS. Standard: Ag25941. Range: 0.313-40 ng/mL.

  • Cytometric bead array standard curve of MP01789-1

    Cytometric bead array standard curve of MP01789-1

    Cytometric bead array standard curve of MP01789-1, ASIC1 Recombinant Matched Antibody Pair, PBS Only. Capture antibody: 85089-1-PBS. Detection antibody: 85089-3-PBS. Standard: Ag25941. Range: 0.313-40 ng/mL.

ASIC1 Recombinant antibody, PBS Only (Capture)

ASIC1 Uni-rAbTM Recombinant Antibody for WB, Cytometric bead array, Indirect ELISA
Cat No. 85089-1-PBS

产品说明书

CloneNo. 242749B11

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, Cytometric bead array, Indirect ELISA

别名

ACCN2, ASIC, Amiloride-sensitive cation channel 2, neuronal, Acid-sensing ion channel 1, 242749B11

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

85089-1-PBS targets ASIC1 as part of a matched antibody pair:

MP01789-1: 85089-1-PBS capture and 85089-3-PBS detection (validated in Cytometric bead array)

MP01789-2: 85089-1-PBS capture and 85089-2-PBS detection (validated in Cytometric bead array)

Unconjugated rabbit recombinant monoclonal antibody in PBS only (BSA and azide free) storage buffer at a concentration of 1 mg/mL, ready for conjugation. Created using Proteintech’s proprietary in-house recombinant technology. Recombinant production enables unrivalled batch-to-batch consistency, easy scale-up, and future security of supply.

This conjugation ready format makes antibodies ideal for use in many applications including: ELISAs, multiplex assays requiring matched pairs, mass cytometry, and multiplex imaging applications.Antibody use should be optimized by the end user for each application and assay.

经测试应用 WB, Cytometric bead array, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原 ASIC1 fusion protein Ag25941 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 amiloride-sensitive cation channel 2, neuronal
别名 ACCN2, ASIC, Amiloride-sensitive cation channel 2, neuronal, Acid-sensing ion channel 1, 242749B11
计算分子量 60 kDa
观测分子量60-70 kDa
GenBank蛋白编号NM_001095
基因名称 ASIC1
Gene ID (NCBI) 41
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purification
UNIPROT IDP78348
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

ASIC1(Acid-sensing ion channel 1), also named as ACCN2, BNaC2 or amiloride-sensitive cation channel 2, is a member of the ASICs family. ASICs, an H+-gated subgroup of the epithelial Na+ channel/degenerin (ENaC/DEG) superfamily, are widely expressed throughout the central and peripheral nervous system and triggered by increased extracellular acidification (PMID: 28518134, 27941930). ASIC1 is a key player in acidosis-induced tumor growth and invasiveness. Clinically, alterations of ASIC1 are associated with poor survival in breast cancer (PMID: 26686084).