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验证数据展示

  • WB analysis of rat eye using 68001-1-Ig (same clone as 68001-1-PBS)

    WB analysis of rat eye using 68001-1-Ig (same clone as 68001-1-PBS)

    rat eye tissue were subjected to SDS PAGE followed by western blot with 68001-1-Ig (aB-Crystallin antibody) at dilution of 1:20000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68001-1-PBS in a different storage buffer formulation.

  • WB analysis of mouse eye using 68001-1-Ig (same clone as 68001-1-PBS)

    WB analysis of mouse eye using 68001-1-Ig (same clone as 68001-1-PBS)

    mouse eye tissue were subjected to SDS PAGE followed by western blot with 68001-1-Ig (aB-Crystallin antibody) at dilution of 1:20000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68001-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse eye using 68001-1-Ig (same clone as 68001-1-PBS)

    IHC staining of mouse eye using 68001-1-Ig (same clone as 68001-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse eye tissue slide using 68001-1-Ig (Alpha B Crystallin antibody) at dilution of 1:2000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 68001-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with CRYAB antibody included

Alpha B Crystallin Monoclonal antibody, PBS Only

Alpha B Crystallin Monoclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 68001-1-PBS

产品说明书

CloneNo. 1B4C3

宿主/亚型

Mouse / IgG2b

种属反应性

Human, mouse, rat

应用

WB, IHC, Indirect ELISA

别名

Alpha crystallin B chain, Alpha(B) crystallin, CRYA2, CRYAB, crystallin, alpha B, CTPP2, Heat shock protein beta 5, HSPB5, Rosenthal fiber component

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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Planning an IHC experiment? We recommend our IHCeasy CRYAB Ready-To-Use IHC Kit. CRYAB primary antibody included.

产品信息

68001-1-PBS targets Alpha B Crystallin in WB, IHC, Indirect ELISA applications and shows reactivity with Human, mouse, rat samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 Human, mouse, rat
免疫原 Alpha B Crystallin fusion protein Ag8656 种属同源性预测
宿主/亚型 Mouse / IgG2b
抗体类别 Monoclonal
产品类型 Antibody
全称 crystallin, alpha B
别名 Alpha crystallin B chain, Alpha(B) crystallin, CRYA2, CRYAB, crystallin, alpha B, CTPP2, Heat shock protein beta 5, HSPB5, Rosenthal fiber component
计算分子量 175 aa, 20 kDa
观测分子量20-22 kDa
GenBank蛋白编号BC007008
基因名称 Alpha B Crystallin
Gene ID (NCBI) 1410
RRIDAB_2918749
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purification
UNIPROT IDP02511
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Alpha B-crystallin, encoded by CRYAB gene, is multifunctional, serving as both a major structural protein in the lens and a small heat-shock protein in other tissues in mammals. Alpha B-crystallin may contribute to the transparency and refractive index of the lens. Single nucleotide polymorphisms (SNPs) in the promoter region of CRYAB gene have been associated with in multiple sclerosis. Mutations in the CRYAB gene cause distinct clinical phenotypes including isolated posterior polar cataract, myofibrillar myopathy, cardiomyopathy, or a multisystemic disorder combining all these features. Impairment of alpha-B crystallin dimerization may be relevant to the pathogenesis of these disorders.