Biotin-conjugated BCL6 Monoclonal antibody
BCL6 Monoclonal Antibody for IHC
Host / Isotype
Mouse / IgG1
Reactivity
human
Applications
IHC
Conjugate
Biotin
CloneNo.
1E6B1
验证数据展示
经过测试的应用
Positive IHC detected in | human tonsillitis tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
推荐稀释比
Application | Dilution |
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Immunohistochemistry (IHC) | IHC : 1:500-1:2000 |
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Sample-dependent, Check data in validation data gallery. |
产品信息
Biotin-66340 targets BCL6 in IHC applications and shows reactivity with human samples.
Tested Applications | IHC Application Description |
Tested Reactivity | human |
Immunogen | BCL6 fusion protein Ag15519 种属同源性预测 |
Host / Isotype | Mouse / IgG1 |
Class | Monoclonal |
Type | Antibody |
Full Name | B-cell CLL/lymphoma 6 |
Synonyms | B cell CLL/lymphoma 6, B cell lymphoma 5 protein, B cell lymphoma 6 protein, BCL6, LAZ3, Protein LAZ 3, ZBTB27, Zinc finger protein 51, ZNF51 |
Calculated Molecular Weight | 706 aa, 79 kDa |
GenBank Accession Number | BC150184 |
Gene Symbol | BCL6 |
Gene ID (NCBI) | 604 |
RRID | AB_2883070 |
Conjugate | Biotin |
Form | Liquid |
Purification Method | Protein G purification |
UNIPROT ID | P41182 |
Storage Buffer | PBS with 50% Glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3. |
Storage Conditions | Store at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
BCl6, a zinc finger transcription factor, contains a N-terminal BTB/POZ domain and C-terminal zinc finger DNA-binding motifs and represses transcription of a wide range of target proteins and microRNAs. BCL6 protein has been reported as a master regulator of B lymphocyte development and growth, and altered BCL6 protein expression was implicated in pathogenesis of diverse human hematologic malignancies, especially in the diffuse large B cell lymphoma (DLBCL). BCL6 is required for the development of T follicular helper T cells (TFH), a helper T cell subset required for the formation of mature and productive GCs. BCL6 has also been shown to play important regulatory roles in macrophages. This antibody only recognize human species.
实验方案
Product Specific Protocols | |
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IHC protocol for Biotin BCL6 antibody Biotin-66340 | Download protocol |
Standard Protocols | |
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Click here to view our Standard Protocols |