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验证数据展示

  • IF Staining of human tonsillitis using CL594-66801

    IF Staining of human tonsillitis using CL594-66801

    Immunofluorescent analysis of (4% PFA) fixed human tonsillitis tissue using CoraLite®594 CCR6 antibody (CL594-66801, Clone: 1C11A9 ) at dilution of 1:200.

  • IF Staining of human tonsillitis using CL594-66801

    IF Staining of human tonsillitis using CL594-66801

    Immunofluorescent analysis of (4% PFA) fixed human tonsillitis tissue using CoraLite®594 CCR6 antibody (CL594-66801, Clone: 1C11A9 ) at dilution of 1:200.

CoraLite®594-conjugated CCR6 Monoclonal antibody

CCR6 Monoclonal Antibody for IF-P
Cat No. CL594-66801

产品说明书

CloneNo. 1C11A9

宿主/亚型

Mouse / IgG2a

种属反应性

Human

应用

IF-P

别名

BN 1, C C chemokine receptor type 6, C C CKR 6, CC CKR 6, CCR 6, CCR6, CD196, Chemokine receptor like 3, CKR L3, CKR6, CKRL3, CMKBR6, DCR2, DRY 6, DRY6, G protein coupled receptor 29, GPR CY4, GPR29, GPRCY4, LARC receptor, STRL22

缓冲液配方:  PBS and Azide
PBS and Azide
偶联物:  CoraLite®594
规格: 

-/ -

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经过测试的应用

Positive IF-P detected inhuman tonsillitis tissue
For other applications, we recommend the unconjugated version of this antibody, 66801-1-Ig

推荐稀释比

应用推荐稀释比
Immunofluorescence (IF)-PIF-P : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

CL594-66801 targets CCR6 in IF-P applications and shows reactivity with Human samples.

经测试应用 IF-P Application Description
经测试反应性 Human
免疫原 CCR6 fusion protein Ag24195 种属同源性预测
宿主/亚型 Mouse / IgG2a
抗体类别 Monoclonal
产品类型 Antibody
全称 chemokine (C-C motif) receptor 6
别名 BN 1, C C chemokine receptor type 6, C C CKR 6, CC CKR 6, CCR 6, CCR6, CD196, Chemokine receptor like 3, CKR L3, CKR6, CKRL3, CMKBR6, DCR2, DRY 6, DRY6, G protein coupled receptor 29, GPR CY4, GPR29, GPRCY4, LARC receptor, STRL22
计算分子量 42 kDa
GenBank蛋白编号BC037960
基因名称 CCR6
Gene ID (NCBI) 1235
RRIDAB_2920041
偶联类型 CoraLite®594 Fluorescent Dye
最大激发/发射波长588 nm / 604 nm
形式 Liquid
纯化方式Protein A purification
UNIPROT IDP51684
储存缓冲液 PBS with 50% glycerol, 0.05% Proclin300, 0.5% BSA , pH 7.3
储存条件Store at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

CCR6, also known CD196, is a C-C chemokine receptor that belongs to family A of G protein-coupled receptor superfamily. It is expressed on most B cells, memory T cells, and some subsets of dendritic cells (PMID: 17057190). CCR6 is a receptor for the C-C type chemokine CCL20 (PMID: 9169459). The ligand-receptor pair CCL20-CCR6 is responsible for the chemoattraction of immature dendritic cells, effector/memory T-cells and B-cells and plays a role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and rheumatoid arthritis (PMID: 12948524). CCR6 polymorphism has been associated with rheumatoid arthritis susceptibility and CCR6 is involved in IL-17-driven autoimmunity in human diseases (PMID: 20453841).

实验方案

Product Specific Protocols
IF protocol for CL594 CCR6 antibody CL594-66801Download protocol
Standard Protocols
Click here to view our Standard Protocols