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Anti-Human CD18 (TS1/18) Mouse IgG2a Recombinant Antibody, PBS Only

CD18 Uni-rAbTM Recombinant Antibody for FC

Host / Isotype

Mouse / IgG2a

Reactivity

human

Applications

FC

Conjugate

Unconjugated

CloneNo.

TS1/18

Cat no : 65595-1-PBS

Print datasheet

Synonyms

ITGB2, LCAMB, LAD, Integrin beta-2, Integrin beta 2

验证数据展示

  • FC experiment of human PBMCs using 65595-1-MR (same clone as 65595-1-PBS)

    FC experiment of human PBMCs using 65595-1-MR (same clone as 65595-1-PBS)

    1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human CD18 Mouse IgG2a Recombinant Antibody (65595-1-MR, Clone: TS1/18) or 0.25 ug Mouse IgG2a Isotype Control (65208-1-Ig, Clone: C1.18.4) and CoraLite®488-Conjugated Donkey Anti-Mouse IgG(H+L). Cells were then stained with APC Anti-Human CD45. Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 65595-1-PBS in a different storage buffer formulation.

  • FC experiment of human PBMCs using 65595-1-MR (same clone as 65595-1-PBS)

    FC experiment of human PBMCs using 65595-1-MR (same clone as 65595-1-PBS)

    1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human CD18 Mouse IgG2a Recombinant Antibody (65595-1-MR, Clone: TS1/18) (red) or 0.25 ug Mouse IgG2a Isotype Control (65208-1-Ig, Clone: C1.18.4) (blue) and CoraLite®488-Conjugated Donkey Anti-Mouse IgG(H+L). Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 65595-1-PBS in a different storage buffer formulation.

产品信息

65595-1-PBS targets CD18 in FC applications and shows reactivity with human samples.

Tested Applications FC Application Description
Tested Reactivity human
Immunogen Human Beta 2 Integrin 种属同源性预测
Host / Isotype Mouse / IgG2a
Class Recombinant
Type Antibody
Full Name integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
Synonyms ITGB2, LCAMB, LAD, Integrin beta-2, Integrin beta 2
Calculated Molecular Weight 85 kDa
GenBank Accession NumberBC005861
Gene Symbol CD18
Gene ID (NCBI) 3689
ENSEMBL Gene IDENSG00000160255
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

CD18, also known as integrin beta-2, is a transmembrane protein that forms heterodimers with CD11a, CD11b, CD11c, CD11d (PMID: 1968349). CD11a/CD18 (LFA-1) is expressed by all leukocytes, while CD11b/CD18 (Mac-1) and CD11c/CD18 (p150,95) are normally restricted to expression on monocytes, macrophages, polymorphonuclear lymphocytes (PMNs), and natural killer cells (PMID: 1968349; 3109455; 10946284). CD18 plays an important role in mediating cell adhesion during immune response and defects of CD18 cause leukocyte adhesion deficiency (PMID: 3594570).