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验证数据展示

  • FC experiment of human peripheral blood leukocytes using Biotin-98012

    FC experiment of human peripheral blood leukocytes using Biotin-98012

    1x10^6 human peripheral blood leukocytes were surface stained with 0.25 ug Biotin Plus Anti-Human CEACAM5/8 (CD66b/e) Rabbit Recombinant Antibody (Biotin-98012, Clone: 230353B7) and CoraLite®488-conjugated streptavidin, or unstained. Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed.

Biotin Anti-Human CEACAM5/8 (CD66b/e) Rabbit Recombinant Antibody

CEACAM5/8 (CD66b/e) Uni-rAbTM Recombinant Antibody for FC
Cat No. Biotin-98012

产品说明书

CloneNo. 230353B7

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

FC

别名

CD66b, CEACAM8, CD 67, CD 66b, Carcinoembryonic antigen-related cell adhesion molecule 8

缓冲液配方:  PBS and Azide
PBS and Azide
偶联物:  Biotin
规格: 

-/ -

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经过测试的应用

Positive FC detected inhuman PBMCs

推荐稀释比

应用推荐稀释比
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

Biotin-98012 targets CEACAM5/8 (CD66b/e) in FC applications and shows reactivity with human samples.

经测试应用 FC Application Description
经测试反应性 human
免疫原 Recombinant protein 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 carcinoembryonic antigen-related cell adhesion molecule 8
别名 CD66b, CEACAM8, CD 67, CD 66b, Carcinoembryonic antigen-related cell adhesion molecule 8
计算分子量 38 kDa
GenBank蛋白编号BC026263
基因名称 CEACAM8
Gene ID (NCBI) 1088
偶联类型 Biotin
形式 Liquid
纯化方式Protein A purification
UNIPROT IDP31997
储存缓冲液 PBS with 0.09% sodium azide , pH 7.3
储存条件Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment.

背景介绍

Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) belong to the immunoglobulin superfamily of cell adhesion molecules. CEACAMs play major roles in cell-cell and cell-ECM adhesion and have been implicated in controlling cell proliferation, angiogenesis, and tissue remodeling (PMID: 23021083). Carcinoembryonic antigen (CEA), also known as CEACAM5 or CD66e mainly serves as a cell adhesion molecule mediating intercellular contact by both homophilic and heterophilic binding (PMID: 21731662). CEACAM8, also known as CD66b, CGM6 or NCA-95, is a glycosylphosphatidylinositol (GPI)-linked glycoprotein expressed on granulocytes and is involved in regulating adhesion and activation of eosinophils (PMID: 8104998; 18056392; 18056392). This antibody is raised against 35-319 aa of human CEACAM8/CD66b and can cross-react with CEACAM5/CD66e.

实验方案

Product Specific Protocols
FC protocol for Biotin CEACAM5/8 (CD66b/e) antibody Biotin-98012Download protocol
Standard Protocols
Click here to view our Standard Protocols