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验证数据展示

  • FC experiment of human peripheral blood leukocytes using CL405-98012

    FC experiment of human peripheral blood leukocytes using CL405-98012

    1x10^6 human peripheral blood leukocytes were surface stained with 5 ul CoraLite® Plus 405 Anti-Human CEACAM5/8 (CD66b/e) Rabbit Recombinant Antibody (CL405-98012, Clone: 230353B7) or Isotype Control. Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed.

CoraLite® Plus 405 Anti-Human CEACAM5/8 (CD66b/e) Rabbit Recombinant Antibody

CEACAM5/8 (CD66b/e) Uni-rAbTM Recombinant Antibody for FC
Cat No. CL405-98012

产品说明书

CloneNo. 230353B7

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

FC

别名

CD66b, CEACAM8, CD 67, CD 66b, Carcinoembryonic antigen-related cell adhesion molecule 8

缓冲液配方:  PBS and Azide
PBS and Azide
偶联物:  CoraLite® Plus 405
规格: 

-/ -

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经过测试的应用

Positive FC detected inhuman peripheral blood leukocytes
For other applications, we recommend the unconjugated version of this antibody, 98012-1-PBS

推荐稀释比

应用推荐稀释比
This reagent has been pre-titrated and tested for flow cytometric analysis. The suggested use of this reagent is 5 ul per 10^6 cells in a 100 µl suspension or 5 ul per 100 µl of whole blood.
Sample-dependent, Check data in validation data gallery.

产品信息

CL405-98012 targets CEACAM5/8 (CD66b/e) in FC applications and shows reactivity with human samples.

经测试应用 FC Application Description
经测试反应性 human
免疫原 Recombinant protein 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 carcinoembryonic antigen-related cell adhesion molecule 8
别名 CD66b, CEACAM8, CD 67, CD 66b, Carcinoembryonic antigen-related cell adhesion molecule 8
计算分子量 38 kDa
GenBank蛋白编号BC026263
基因名称 CEACAM8
Gene ID (NCBI) 1088
RRIDAB_3672407
偶联类型 CoraLite® Plus 405 Fluorescent Dye
最大激发/发射波长399 nm / 422 nm
形式 Liquid
纯化方式Protein A purification
UNIPROT IDP31997
储存缓冲液 PBS with 0.09% sodium azide and 0.5% BSA , pH 7.3
储存条件Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment.

背景介绍

Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) belong to the immunoglobulin superfamily of cell adhesion molecules. CEACAMs play major roles in cell-cell and cell-ECM adhesion and have been implicated in controlling cell proliferation, angiogenesis, and tissue remodeling (PMID: 23021083). Carcinoembryonic antigen (CEA), also known as CEACAM5 or CD66e mainly serves as a cell adhesion molecule mediating intercellular contact by both homophilic and heterophilic binding (PMID: 21731662). CEACAM8, also known as CD66b, CGM6 or NCA-95, is a glycosylphosphatidylinositol (GPI)-linked glycoprotein expressed on granulocytes and is involved in regulating adhesion and activation of eosinophils (PMID: 8104998; 18056392; 18056392). This antibody is raised against 35-319 aa of human CEACAM8/CD66b and can cross-react with CEACAM5/CD66e.

实验方案

Product Specific Protocols
FC protocol for CL Plus 405 CEACAM5/8 (CD66b/e) antibody CL405-98012Download protocol
Standard Protocols
Click here to view our Standard Protocols