验证数据展示
产品信息
84668-4-PBS targets CEBP Alpha/CEBPA in IF/ICC, FC (Intra), Indirect ELISA applications and shows reactivity with human samples.
| 经测试应用 | IF/ICC, FC (Intra), Indirect ELISA Application Description |
| 经测试反应性 | human |
| 免疫原 | CEBP Alpha/CEBPA fusion protein Ag29947 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Recombinant |
| 产品类型 | Antibody |
| 全称 | CCAAT/enhancer binding protein (C/EBP), alpha |
| 别名 | CEBP alpha, CEBPA, CEBP, CCAAT/enhancer-binding protein alpha, C/EBPα |
| 计算分子量 | 38 kDa |
| 观测分子量 | 40-45 kDa |
| GenBank蛋白编号 | NM_004364 |
| 基因名称 | CEBPA |
| Gene ID (NCBI) | 1050 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein A purfication |
| UNIPROT ID | P49715 |
| 储存缓冲液 | PBS only , pH 7.3 |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
CEBPA and its isoforms play important roles in lineage determination and gene activation in a variety of cell types by activating transcription from lineage-specific promoters. CEBPA is a DNA-binding protein that recognizes two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. In hematopoiesis, C/EBPa is a key factor in driving the development of myeloid cells interacting with a variety of factors, including c-Myc, PU.1, and microRNAs. It can also form heterodimers with the related proteins CEBP-beta and CEBP-gamma. The encoded protein has been shown to bind to the promoter and modulate the expression of the gene encoding leptin which plays an important role in body weight homeostasis. CEBPA can interact with CDK2 and CDK4, thereby inhibiting these kinases and causing growth arrest in cultured cells. Several pathways have been implicated as the means by which CEBPA mediates cell cycle arrest and proliferation, including p21, cyclin-dependent kinases and the E2F complex via c-Myc.
