验证数据展示
产品信息
68853-7-PBS targets CLCC1 in WB, Indirect ELISA applications and shows reactivity with human samples.
Tested Applications | WB, Indirect ELISA Application Description |
Tested Reactivity | human |
Immunogen | CLCC1 fusion protein Ag24682 种属同源性预测 |
Host / Isotype | Mouse / IgG1 |
Class | Monoclonal |
Type | Antibody |
Full Name | chloride channel CLIC-like 1 |
Synonyms | Mid-1-related chloride channel protein 1, MCLC, KIAA0761, Chloride channel CLIC-like protein 1, chloride channel CLIC like 1 |
Calculated Molecular Weight | 551 aa, 62 kDa |
Observed Molecular Weight | 50-60 kDa |
GenBank Accession Number | BC002939 |
Gene Symbol | CLCC1 |
Gene ID (NCBI) | 23155 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein G purification |
UNIPROT ID | Q96S66 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
CLCC1, also known as MCLC, is a transmembrane protein that localizes to intracellular compartments, including endoplasmic reticulum (ER), and it functions as a chloride channel (PMID: 11279057). It has been shown that loss of CLCC1 results in ER Stress, misfolded protein accumulation, and neurodegeneration (PMID: 25698737). CLCC1 forms homomultimer in the ER membrane and is a pore-forming component of an anion channel. Studies found that disruption of ER ion homeostasis maintained by CLCC1 is one of the causes of neurodegenerative diseases, such as ALS (amyotrophic lateral sclerosis) (PMID: 37142673).