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Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

验证数据展示

  • FC experiment of human peripheral blood leukocytes using 98083-1-RR (same clone as 98083-1-PBS)

    FC experiment of human peripheral blood leukocytes using 98083-1-RR (same clone as 98083-1-PBS)

    1x10^6 human peripheral blood leukocytes were surface stained with 0.25 ug Anti-Human CLEC12A Rabbit Recombinant Antibody (98083-1-RR, Clone:240791B7), or Isotype Control and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were then stained with CoraLite® Plus 647 Anti-Human CD16. Cells were incubated with FC Receptor Block prior to fixing and staining. Cells were not fixed. This data was developed using the same antibody clone with 98083-1-PBS in a different storage buffer formulation.

  • FC experiment of human peripheral blood leukocytes using 98083-1-RR (same clone as 98083-1-PBS)

    FC experiment of human peripheral blood leukocytes using 98083-1-RR (same clone as 98083-1-PBS)

    1x10^6 human peripheral blood leukocytes were surface stained with 0.25 ug Anti-Human CLEC12A Rabbit Recombinant Antibody (98083-1-RR, Clone:240791B7)(red), or 0.25 ug Isotype Control(blue) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were incubated with FC Receptor Block prior to fixing and staining.Cells were not fixed. This data was developed using the same antibody clone with 98083-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 98083-1-RR

    Affinity and Kinetic Characterization of 98083-1-RR

    Biolayer interferometry (BLl) kinetic assays of 98083-1-RR against Human CLEC12A were performed. The affinity constant is 0.524 nM.

Anti-Human CLEC12A Rabbit Recombinant Antibody, PBS Only

CLEC12A Uni-rAbTM Recombinant Antibody for FC
Cat No. 98083-1-PBS
CloneNo. 240791B7

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

FC

Synonyms

CLL-1, CLL1, CLL 1, CD371, C type lectin like molecule 1

Formulation:  PBS Only
PBS and Azide
PBS Only
Conjugate:  Unconjugated
Size: 

-/ -

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Planning an IHC experiment? We recommend our IHCeasy CLEC12A Ready-To-Use IHC Kit. CLEC12A primary antibody included.

产品信息

98083-1-PBS targets CLEC12A in FC applications and shows reactivity with human samples.

Tested Applications FC Application Description
Tested Reactivity human
Immunogen Fusion Protein 种属同源性预测
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Full Name C-type lectin domain family 12, member A
Synonyms CLL-1, CLL1, CLL 1, CD371, C type lectin like molecule 1
Calculated Molecular Weight31 kDa
GenBank Accession NumberBC126291
Gene Symbol CLEC12A
Gene ID (NCBI) 160364
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
UNIPROT IDQ5QGZ9
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

CLEC12A, also known as CD371, MICL, DCAL-2 or CLL-1, is a type II transmembrane glycoprotein and a member of the C-type lectin superfamily (PMID: 30401586). This protein, which contains a single C-type lectin-like domain and a cytoplasmic immunoreceptor tyrosine-based inhibitory motif (ITIM), is related to LOX-1 and Dectin-1 and is variably spliced and highly N-glycosylated (PMID: 14739280). Its ITIM sequence recruits the tyrosine phosphatases SHP-1 and SHP-2 to negatively regulate Syk signaling. In humans, CLEC12A is mainly expressed on myeloid cells, being found on monocytes, granulocytes, macrophages and DC subsets, and at lower levels on CD4+ T cells (PMID: 32477350). The observed molecular weight of CLEC12A is between 40 and 75 kDa, which is much higher than the predicted molecular weight due to glycosylation (PMID: 14739280).