CNTN1 Monoclonal antibody

CNTN1 Monoclonal Antibody for WB, ELISA

Host / Isotype

Mouse / IgG1

Reactivity

Human, pig, rabbit

Applications

WB, ELISA

Conjugate

Unconjugated

CloneNo.

1C1D4

Cat no : 68252-1-Ig

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Synonyms

CNTN1, contactin 1, F3, Glycoprotein gp135, GP135, Neural cell surface protein F3



经过测试的应用

Positive WB detected inA549 cells, pig cerebellum tissue, pig brain tissue, rabbit brain tissue, rabbit cerebellum tissue

推荐稀释比

ApplicationDilution
Western Blot (WB)WB : 1:5000-1:50000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

68252-1-Ig targets CNTN1 in WB, ELISA applications and shows reactivity with Human, pig, rabbit samples.

Tested Applications WB, ELISA Application Description
Tested Reactivity Human, pig, rabbit
Immunogen CNTN1 fusion protein Ag5030 种属同源性预测
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Full Name contactin 1
Synonyms CNTN1, contactin 1, F3, Glycoprotein gp135, GP135, Neural cell surface protein F3
Calculated Molecular Weight 1018 aa, 113 kDa
Observed Molecular Weight130-135 kDa
GenBank Accession NumberBC036569
Gene Symbol CNTN1
Gene ID (NCBI) 1272
Conjugate Unconjugated
Form Liquid
Purification MethodProtein G purification
UNIPROT IDQ12860
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

Contactin-1 (CNTN1), also known as Glycoprotein gp135 or Neural cell surface protein F3, is a neuronal cell adhesion molecule of the immunoglobulin superfamily (PMID: 3049624). It consists of six Ig domains, four fibronectin-like motifs, and a glycosylphosphatidylinositol (GPI)-moiety. Expressed by the central and peripheral neurons, CNTN1 contributes to the formation and function of neuronal connections. It plays a role in axon extension and formation of septate-like junctions between axons and myelinating glial cells (PMID: 23724143). In addition, acting as a ligand for Notch, CNTN1 initiates a NOTCH/DTX1 signaling pathway that promotes oligodendrocyte maturation and myelination (PMID: 14567914).

实验方案

Product Specific Protocols
WB protocol for CNTN1 antibody 68252-1-IgDownload protocol
Standard Protocols
Click here to view our Standard Protocols