CNTN1 Monoclonal antibody, PBS Only

CNTN1 Monoclonal Antibody for WB, Indirect ELISA

Host / Isotype

Mouse / IgG1

Reactivity

Human, pig, rabbit

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

1C1D4

Cat no : 68252-1-PBS

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Synonyms

CNTN1, contactin 1, F3, Glycoprotein gp135, GP135, Neural cell surface protein F3



产品信息

68252-1-PBS targets CNTN1 in WB, Indirect ELISA applications and shows reactivity with Human, pig, rabbit samples.

Tested Applications WB, Indirect ELISA Application Description
Tested Reactivity Human, pig, rabbit
Immunogen CNTN1 fusion protein Ag5030 种属同源性预测
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Full Name contactin 1
Synonyms CNTN1, contactin 1, F3, Glycoprotein gp135, GP135, Neural cell surface protein F3
Calculated Molecular Weight 1018 aa, 113 kDa
Observed Molecular Weight130-135 kDa
GenBank Accession NumberBC036569
Gene Symbol CNTN1
Gene ID (NCBI) 1272
Conjugate Unconjugated
Form Liquid
Purification MethodProtein G purification
UNIPROT IDQ12860
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Contactin-1 (CNTN1), also known as Glycoprotein gp135 or Neural cell surface protein F3, is a neuronal cell adhesion molecule of the immunoglobulin superfamily (PMID: 3049624). It consists of six Ig domains, four fibronectin-like motifs, and a glycosylphosphatidylinositol (GPI)-moiety. Expressed by the central and peripheral neurons, CNTN1 contributes to the formation and function of neuronal connections. It plays a role in axon extension and formation of septate-like junctions between axons and myelinating glial cells (PMID: 23724143). In addition, acting as a ligand for Notch, CNTN1 initiates a NOTCH/DTX1 signaling pathway that promotes oligodendrocyte maturation and myelination (PMID: 14567914).