验证数据展示
产品信息
68252-1-PBS targets CNTN1 in WB, Indirect ELISA applications and shows reactivity with Human, pig, rabbit samples.
| Tested Applications | WB, Indirect ELISA Application Description |
| Tested Reactivity | Human, pig, rabbit |
| Immunogen | CNTN1 fusion protein Ag5030 种属同源性预测 |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Full Name | contactin 1 |
| Synonyms | CNTN1, contactin 1, F3, Glycoprotein gp135, GP135, Neural cell surface protein F3 |
| Calculated Molecular Weight | 1018 aa, 113 kDa |
| Observed Molecular Weight | 130-135 kDa |
| GenBank Accession Number | BC036569 |
| Gene Symbol | CNTN1 |
| Gene ID (NCBI) | 1272 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Protein G purification |
| UNIPROT ID | Q12860 |
| Storage Buffer | PBS Only |
| Storage Conditions | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Contactin-1 (CNTN1), also known as Glycoprotein gp135 or Neural cell surface protein F3, is a neuronal cell adhesion molecule of the immunoglobulin superfamily (PMID: 3049624). It consists of six Ig domains, four fibronectin-like motifs, and a glycosylphosphatidylinositol (GPI)-moiety. Expressed by the central and peripheral neurons, CNTN1 contributes to the formation and function of neuronal connections. It plays a role in axon extension and formation of septate-like junctions between axons and myelinating glial cells (PMID: 23724143). In addition, acting as a ligand for Notch, CNTN1 initiates a NOTCH/DTX1 signaling pathway that promotes oligodendrocyte maturation and myelination (PMID: 14567914).
