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CoraLite® Plus 488-conjugated COPS2 Monoclonal antibody

COPS2 Monoclonal Antibody for IF-P

Host / Isotype

Mouse / IgG1

Reactivity

human, mouse, rat

Applications

IF-P

Conjugate

CoraLite® Plus 488 Fluorescent Dye

CloneNo.

2H10E6

Cat no : CL488-66435

Print datasheet

Synonyms

ALIEN, Alien homolog, COPS2, CSN2, SGN2, Signalosome subunit 2, TR interacting protein 15, TRIP 15, TRIP15

验证数据展示

  • IF Staining of human ovary cancer using CL488-66435

    IF Staining of human ovary cancer using CL488-66435

    Immunofluorescent analysis of (4% PFA) fixed human ovary cancer cells using CoraLite® Plus 488 COPS2 antibody (CL488-66435, Clone: 2H10E6 ) at dilution of 1:200.

经过测试的应用

Positive IF-P detected inhuman ovary cancer cells
Planning an IHC experiment? We recommend our IHCeasy COPS2 Ready-To-Use IHC Kit. COPS2 primary antibody included.
For other applications, we recommend the unconjugated version of this antibody, 66435-1-Ig

推荐稀释比

ApplicationDilution
Immunofluorescence (IF)-PIF-P : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

CL488-66435 targets COPS2 in IF-P applications and shows reactivity with human, mouse, rat samples.

Tested Applications IF-P Application Description
Tested Reactivity human, mouse, rat
Immunogen COPS2 fusion protein Ag1415 种属同源性预测
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Full Name COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis)
Synonyms ALIEN, Alien homolog, COPS2, CSN2, SGN2, Signalosome subunit 2, TR interacting protein 15, TRIP 15, TRIP15
Calculated Molecular Weight 52 kDa
Observed Molecular Weight 52 kDa
GenBank Accession NumberBC012629
Gene Symbol COPS2
Gene ID (NCBI) 9318
RRIDAB_2919323
Conjugate CoraLite® Plus 488 Fluorescent Dye
Excitation/Emission Maxima Wavelengths493 nm / 522 nm
Form Liquid
Purification MethodProtein G purification
UNIPROT IDP61201
Storage Buffer PBS with 50% Glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3.
Storage ConditionsStore at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

COPS2 is an essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

实验方案

Product Specific Protocols
IF protocol for CL Plus 488 COPS2 antibody CL488-66435Download protocol
Standard Protocols
Click here to view our Standard Protocols