验证数据展示
产品信息
68200-1-PBS targets CSNK2A1 in WB, IF/ICC, Indirect ELISA applications and shows reactivity with human, rabbit samples.
经测试应用 | WB, IF/ICC, Indirect ELISA Application Description |
经测试反应性 | human, rabbit |
免疫原 | CSNK2A1 fusion protein Ag29062 种属同源性预测 |
宿主/亚型 | Mouse / IgG1 |
抗体类别 | Monoclonal |
产品类型 | Antibody |
全称 | casein kinase 2, alpha 1 polypeptide |
别名 | CKII, CK2α, CK2A1, CK2a, CK II alpha |
计算分子量 | 45 kDa |
观测分子量 | 40-45 kDa |
GenBank蛋白编号 | BC011668 |
基因名称 | CSNK2A1 |
Gene ID (NCBI) | 1457 |
偶联类型 | Unconjugated |
形式 | Liquid |
纯化方式 | Protein G purification |
UNIPROT ID | P68400 |
储存缓冲液 | PBS only , pH 7.3 |
储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
CSNK2A1(Casein kinase II subunit alpha) is also named as CK2A1 and belongs to the CK2 subfamily. The CSNK2A1 gene contains 8 exons whose sequences comprise bases 102 to 824 of the coding region of the human casein kinase II alpha subunit. Casein kinase II is a ubiquitous protein-serine/threonine kinase in eukaryotic cells that catalyzes the phosphorylation of many protein substrates and has been regarded as a second-messenger-independent protein kinase. This enzyme is composed of an α subunit (37 to 44kDa) and a β subunit (24 to 28 kDa) and exists as an α2β2 tetramer (PMID:1448100). Casein kinase 2 has been found to be increased at protein level and up-regulated at the level of enzyme activity in the majority of cancers. However, elevated levels of casein kinase 2 are present in certain normal organs such as brain and testes.