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CUL4A Monoclonal antibody, PBS Only

CUL4A Monoclonal Antibody for WB, IHC, IF/ICC, IP, Indirect ELISA
Cat No. 66038-1-PBS

产品说明书

CloneNo. 1A7F12

宿主/亚型

Mouse / IgG1

种属反应性

human, monkey, mouse, rat, pig

应用

WB, IHC, IF/ICC, IP, Indirect ELISA

CUL 4A, CUL4A, cullin 4A

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -


Planning an IHC experiment? We recommend our IHCeasy CUL4A Ready-To-Use IHC Kit. CUL4A primary antibody included.

产品信息

66038-1-PBS targets CUL4A in WB, IHC, IF/ICC, IP, Indirect ELISA applications and shows reactivity with human, monkey, mouse, rat, pig samples.

经测试应用 WB, IHC, IF/ICC, IP, Indirect ELISA Application Description
经测试反应性 human, monkey, mouse, rat, pig
免疫原 CUL4A fusion protein Ag18089 种属同源性预测
宿主/亚型 Mouse / IgG1
抗体类别 Monoclonal
产品类型 Antibody
全称 cullin 4A
别名 CUL 4A, CUL4A, cullin 4A
计算分子量 77 kDa
观测分子量 77 kDa, 88 kDa
GenBank蛋白编号BC008308
基因名称 CUL4A
Gene ID (NCBI) 8451
RRIDAB_11042446
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purification
UNIPROT IDQ13619
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Cullin proteins assemble a large number of RING E3 ubiquitin ligases, participating in the proteolysis through the ubiquitin-proteasome pathway. Two cullin 4 (CUL4) proteins, CUL4A (87 kDa) and CUL4B(104 kDa), have been identified. The two CUL4 sequences are 83% identical. They target certain proteins for degradation by binding protein DDB1 to form a CUL4-DDB1 ubiquitin ligase complex with DDB. They form two individual E3 ligases, DDB1-CUL4ADDB2 and DDB1-CUL4BDDB2 in this process. CUL4A appeared in both the nucleus and the cytosol, suggesting a more complex mechanism for entering the nucleus. CUL4B is localized in the nucleus and facilitates the transfer of DDB1 into the nucleus independently of DDB2.

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