CoraLite® Plus 488-conjugated FBXO32 Monoclonal antibody
FBXO32 Monoclonal Antibody for IF-P
Host / Isotype
Mouse / IgG2b
Reactivity
Human, mouse
Applications
IF-P
Conjugate
CoraLite® Plus 488 Fluorescent Dye
CloneNo.
3C2G3
验证数据展示
经过测试的应用
| Positive IF-P detected in | mouse skeletal muscle tissue |
Planning an IHC experiment? We recommend our IHCeasy FBXO32 Ready-To-Use IHC Kit. FBXO32 primary antibody included.
For other applications, we recommend the unconjugated version of this antibody, 67172-1-Ig
推荐稀释比
| Application | Dilution |
|---|---|
| Immunofluorescence (IF)-P | IF-P : 1:50-1:500 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
产品信息
CL488-67172 targets FBXO32 in IF-P applications and shows reactivity with Human, mouse samples.
| Tested Applications | IF-P Application Description |
| Tested Reactivity | Human, mouse |
| Immunogen | FBXO32 fusion protein Ag25247 种属同源性预测 |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Full Name | F-box protein 32 |
| Synonyms | Atrogin 1, F box only protein 32, F box protein 32, Fbx32, FBXO32, FLJ32424, MAFbx, Muscle atrophy F box protein |
| Calculated Molecular Weight | 355 aa, 42 kDa |
| Observed Molecular Weight | 42 kDa |
| GenBank Accession Number | BC024030 |
| Gene Symbol | FBXO32 |
| Gene ID (NCBI) | 114907 |
| Conjugate | CoraLite® Plus 488 Fluorescent Dye |
| Excitation/Emission Maxima Wavelengths | 493 nm / 522 nm |
| Form | Liquid |
| Purification Method | Protein A purification |
| UNIPROT ID | Q969P5 |
| Storage Buffer | PBS with 50% Glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3. |
| Storage Conditions | Store at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
FBXO32 (F box only protein 32), also known as Atrogin 1 or MAFbx, is a member of the F-box protein family which is characterized by an approximately 40 amino acid motif F-box. This protein is an E3 ubiquitin ligase that is markedly up-regulated in muscle atrophy. FBXO32 is thus a potential drug target for the treatment of muscle atrophy. Some data support that FBXO32 may play an important role in tumorigenesis. Recent study reveal that FBXO32 targets the oncogenic protein c-Myc for ubiquitination and degradation through the proteasome pathway.
实验方案
| Product Specific Protocols | |
|---|---|
| IF protocol for CL Plus 488 FBXO32 antibody CL488-67172 | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |