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验证数据展示

  • IF Staining of HeLa using CL594-67133

    IF Staining of HeLa using CL594-67133

    Immunofluorescent analysis of (4% PFA) fixed HeLa cells using CoraLite®594-conjugated FLNA antibody (CL594-67133, Clone: 1G4H3 ) at dilution of 1:400.

CoraLite®594-conjugated FLNA Monoclonal antibody

FLNA Monoclonal Antibody for IF/ICC
Cat No. CL594-67133

产品说明书

CloneNo. 1G4H3

宿主/亚型

Mouse / IgG2a

种属反应性

Human

应用

IF/ICC

别名

ABP 280, ABPX, Actin binding protein 280, Alpha filamin, DKFZp434P031, Filamin 1, Filamin A, FLN, FLN A, FLN1, FLNA, FMD, MNS, NHBP, Non muscle filamin, OPD, OPD1, OPD2

缓冲液配方:  PBS and Azide
PBS and Azide
偶联物:  CoraLite®594
规格: 

-/ -

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经过测试的应用

Positive IF/ICC detected inHeLa cells
Planning an IHC experiment? We recommend our IHCeasy FLNA Ready-To-Use IHC Kit. FLNA primary antibody included.
For other applications, we recommend the unconjugated version of this antibody, 67133-1-Ig

推荐稀释比

应用推荐稀释比
Immunofluorescence (IF)/ICCIF/ICC : 1:200-1:800
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

CL594-67133 targets FLNA in IF/ICC applications and shows reactivity with Human samples.

经测试应用 IF/ICC Application Description
经测试反应性 Human
免疫原 FLNA fusion protein Ag23291 种属同源性预测
宿主/亚型 Mouse / IgG2a
抗体类别 Monoclonal
产品类型 Antibody
全称 filamin A, alpha (actin binding protein 280)
别名 ABP 280, ABPX, Actin binding protein 280, Alpha filamin, DKFZp434P031, Filamin 1, Filamin A, FLN, FLN A, FLN1, FLNA, FMD, MNS, NHBP, Non muscle filamin, OPD, OPD1, OPD2
计算分子量 2647 aa, 280 kDa
观测分子量 280 kDa
GenBank蛋白编号BC014654
基因名称 FLNA
Gene ID (NCBI) 2316
RRIDAB_2883639
偶联类型 CoraLite®594 Fluorescent Dye
最大激发/发射波长588 nm / 604 nm
形式 Liquid
纯化方式Protein A purification
UNIPROT IDP21333
储存缓冲液 PBS with 50% glycerol, 0.05% Proclin300, 0.5% BSA , pH 7.3
储存条件Store at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

FLNA encodes a 280 kDa widely expressed actin binding protein called filamin A which can crosslinks actin filaments and links actin filaments to membrane glycoproteins to form a three-dimensional network (PMID: 29931263). And filamin A could interact with many other proteins, involved in receptor activation, cell migration and adhesion, cell proliferation, inflammation and tumorigenesis, studies have been reported that FLNA overexpressed in multiple types of tumors, suggesting FLNA may involved in cancer aggressiveness(PMID: 29100390). What's more, FLNA is an causative gene of periventricular nodular heterotopia (PNH).(PMID: 29062687)

实验方案

Product Specific Protocols
IF protocol for CL594 FLNA antibody CL594-67133Download protocol
Standard Protocols
Click here to view our Standard Protocols