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GFRAL Polyclonal antibody, PBS Only

GFRAL Polyclonal Antibody for WB, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

Cat no : 28335-1-PBS

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Synonyms

验证数据展示

  • WB analysis using 28335-1-AP (same clone as 28335-1-PBS)

    WB analysis using 28335-1-AP (same clone as 28335-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 28335-1-AP (GFRAL antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 28335-1-PBS in a different storage buffer formulation.

产品信息

28335-1-PBS targets GFRAL in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Applications WB, Indirect ELISA Application Description
Tested Reactivity human, mouse, rat
Immunogen GFRAL fusion protein Ag28504 种属同源性预测
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Full Name GDNF family receptor alpha like
Synonyms
Calculated Molecular Weight 45 aa, 85 kDa
Observed Molecular Weight 45-60 kDa
GenBank Accession NumberNM_207410
Gene Symbol GFRAL
Gene ID (NCBI) 389400
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

GFRAL (GDNF family receptor alpha-like), also called C6orf144, is the brainstem-restricted receptor for GDF15 hormone, which triggers an aversive response, characterized by nausea, vomiting, and/or loss of appetite in response to various stresses (PMID: 28846097, 28846098, 28846099, 28953886, 36630958). The GDF15-GFRAL signal induces expression of genes involved in metabolism, such as lipid metabolism in adipose tissues (PMID: 32661391). GFRAL is a single-pass membrane protein, and localizes to the plasma membrane. It is mainly expressed in the hindbrain, and its mainstream molecular weight is 45-60 kd.