验证数据展示
产品信息
60337-1-PBS targets HEXA in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat, rabbit samples.
| 经测试应用 | WB, Indirect ELISA Application Description |
| 经测试反应性 | human, mouse, rat, rabbit |
| 免疫原 | HEXA fusion protein Ag1854 种属同源性预测 |
| 宿主/亚型 | Mouse / IgG2b |
| 抗体类别 | Monoclonal |
| 产品类型 | Antibody |
| 全称 | hexosaminidase A (alpha polypeptide) |
| 别名 | HEXA, Hexosaminidase subunit A, TSD |
| 计算分子量 | 529 aa, 60 kDa |
| 观测分子量 | 50-54 kDa, 60-67 kDa |
| GenBank蛋白编号 | BC018927 |
| 基因名称 | HEXA |
| Gene ID (NCBI) | 3073 |
| RRID | AB_2881446 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein A purification |
| UNIPROT ID | P06865 |
| 储存缓冲液 | PBS only , pH 7.3 |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Beta-hexosaminidase subunit alpha is involved in catalysis of degradation of the ganglioside GM2. Disfunction of beta-hexosaminidase leads to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses. The enzyme is composed of two subunits, alpha and beta. This gene encodes alpha subunit of beta-hexosaminidase. Western blot with this antibody raised against HEXA detected 60 kDa (precursor) and 54 kDa (mature) size bands (PMID: 27682588, PMID: 30341570).
