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验证数据展示

  • WB analysis using 67106-1-Ig (same clone as 67106-1-PBS)

    WB analysis using 67106-1-Ig (same clone as 67106-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 67106-1-Ig (IDE antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67106-1-PBS in a different storage buffer formulation.

  • WB analysis of HeLa using 67106-1-Ig (same clone as 67106-1-PBS)

    WB analysis of HeLa using 67106-1-Ig (same clone as 67106-1-PBS)

    WB result of IDE antibody (67106-1-Ig; 1:10000; incubated at room temperature for 1.5 hours) with sh-Control and sh-IDE transfected HeLa cells. This data was developed using the same antibody clone with 67106-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse liver using 67106-1-Ig (same clone as 67106-1-PBS)

    IHC staining of mouse liver using 67106-1-Ig (same clone as 67106-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse liver tissue slide using 67106-1-Ig (IDE antibody) at dilution of 1:1000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 67106-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse liver using 67106-1-Ig (same clone as 67106-1-PBS)

    IHC staining of mouse liver using 67106-1-Ig (same clone as 67106-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse liver tissue slide using 67106-1-Ig (IDE antibody) at dilution of 1:1000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 67106-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO验证

IDE Monoclonal antibody, PBS Only

IDE Monoclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 67106-1-PBS

产品说明书

CloneNo. 3E10G1

宿主/亚型

Mouse / IgG2b

种属反应性

human, mouse, rat

应用

WB, IHC, Indirect ELISA

别名

Insulin-degrading enzyme, Insulinase, Insulin protease, EC:3.4.24.56, Abeta-degrading protease

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

67106-1-PBS targets IDE in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原 IDE fusion protein Ag17161 种属同源性预测
宿主/亚型 Mouse / IgG2b
抗体类别 Monoclonal
产品类型 Antibody
全称 Abeta degrading protease
别名 Insulin-degrading enzyme, Insulinase, Insulin protease, EC:3.4.24.56, Abeta-degrading protease
计算分子量 1019 aa, 118 kDa
观测分子量 100-120 kDa
GenBank蛋白编号BC096336
基因名称 IDE
Gene ID (NCBI) 3416
RRIDAB_2882410
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purification
UNIPROT IDP14735
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

IDE(INS-degrading enzyme) belongs to the peptidase M16 family. It is also known as insulysin and is a 110-kD neutral metallopeptidase that can degrade a number of peptides, including INS and beta-amyloid(PMID:9830016). The reduction of IDE expression may be a risk factor for AD, and that IDE may interact with APOE status to affect beta-amyloid metabolism(PMID:12507914). It can exsit as a homodimer and form higher oligomers(PMID:17613531).