• All
  • Primary Antibodies
  • Conjugated Antibodies for IF
  • Conjugated Antibodies for FC
  • Secondary Antibodies
  • Antibody Labeling KitsNew
  • ELISA Kits
  • IHC Kits
  • Magnetic Cell Separation Kits
  • Cytokines & Growth Factors
  • Neutralizing/activating Antibodies
  • Nanobody-based Reagents
  • Accessory Products and Kits
  • Fusion Proteins
×
×
Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0
  • Featured Product
  • KD/KO Validated

IDE Monoclonal antibody, PBS Only

IDE Monoclonal Antibody for WB, Indirect ELISA

Host / Isotype

Mouse / IgG2b

Reactivity

Human, Mouse, Rat

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

3E10G1

Cat no : 67106-1-PBS

Print datasheet

Synonyms

Abeta degrading protease, FLJ35968, IDE, INSULYSIN

验证数据展示

  • WB analysis using 67106-1-Ig (same clone as 67106-1-PBS)

    WB analysis using 67106-1-Ig (same clone as 67106-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 67106-1-Ig (IDE antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67106-1-PBS in a different storage buffer formulation.

  • WB analysis of HeLa using 67106-1-Ig (same clone as 67106-1-PBS)

    WB analysis of HeLa using 67106-1-Ig (same clone as 67106-1-PBS)

    WB result of IDE antibody (67106-1-Ig; 1:10000; incubated at room temperature for 1.5 hours) with sh-Control and sh-IDE transfected HeLa cells. This data was developed using the same antibody clone with 67106-1-PBS in a different storage buffer formulation.

产品信息

67106-1-PBS targets IDE in WB, Indirect ELISA applications and shows reactivity with Human, Mouse, Rat samples.

Tested Applications WB, Indirect ELISA Application Description
Tested Reactivity Human, Mouse, Rat
Immunogen IDE fusion protein Ag17161 种属同源性预测
Host / Isotype Mouse / IgG2b
Class Monoclonal
Type Antibody
Full Name Abeta degrading protease
Synonyms Abeta degrading protease, FLJ35968, IDE, INSULYSIN
Calculated Molecular Weight 1019 aa, 118 kDa
Observed Molecular Weight 100-120 kDa
GenBank Accession NumberBC096336
Gene Symbol IDE
Gene ID (NCBI) 3416
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDP14735
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

IDE(INS-degrading enzyme) belongs to the peptidase M16 family. It is also known as insulysin and is a 110-kD neutral metallopeptidase that can degrade a number of peptides, including INS and beta-amyloid(PMID:9830016). The reduction of IDE expression may be a risk factor for AD, and that IDE may interact with APOE status to affect beta-amyloid metabolism(PMID:12507914). It can exsit as a homodimer and form higher oligomers(PMID:17613531).