CoraLite®555-conjugated IRE1; ERN1 Polyclonal antibody
IRE1; ERN1 Polyclonal Antibody for
Host / Isotype
Rabbit / IgG
Reactivity
Human
Applications
Conjugate
CoraLite®555 Fluorescent Dye
验证数据展示
For other applications, we recommend the unconjugated version of this antibody, 27528-1-AP
产品信息
CL555-27528 targets IRE1; ERN1 in applications and shows reactivity with Human samples.
| Tested Applications | Application Description |
| Tested Reactivity | Human |
| Immunogen | IRE1; ERN1 fusion protein Ag25580 种属同源性预测 |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Full Name | endoplasmic reticulum to nucleus signaling 1 |
| Synonyms | ERN1, FLJ30999, hIRE1p, Inositol requiring protein 1, IRE1, Ire1 alpha, IRE1; ERN1, IRE1P, IRE1α |
| Calculated Molecular Weight | 977 aa, 110 kDa |
| Observed Molecular Weight | 130 kDa |
| GenBank Accession Number | BC130405 |
| Gene Symbol | ERN1 |
| Gene ID (NCBI) | 2081 |
| Conjugate | CoraLite®555 Fluorescent Dye |
| Excitation/Emission Maxima Wavelengths | 557 nm / 570 nm |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | O75460 |
| Storage Buffer | PBS with 50% Glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3. |
| Storage Conditions | Store at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
Inositol-requiring enzyme 1 (IRE1) is an ER transmembrane sensor that activates the UPR to maintain the ER and cellular function. Although mammalian IRE1 promotes cell survival, it can initiate apoptosis via decay of antiapoptotic miRNAs. IRE1 contains a ribonuclease domain in its cytoplasmic region which initiates splicing reaction by direct cleavage of XBP1 mRNA at the two stem loop structures. IRE1 plays instrumental protumoral roles in several cancers, and high IRE1 activity has been associated with poorer prognoses. (PMID: 23880584, PMID: 32861679, PMID: 31875595)