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Anti-Human Jagged1/CD339 Rabbit Recombinant Antibody, PBS Only

Jagged1/CD339 Uni-rAbTM Recombinant Antibody for FC

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

FC

Conjugate

Unconjugated

CloneNo.

241412A6

Cat no : 98243-1-PBS

Print datasheet

Synonyms

Jagged1, JAG1, Protein jagged-1, HJ1, CD339

验证数据展示

  • FC experiment of Transfected HEK-293T using 98243-1-RR (same clone as 98243-1-PBS)

    FC experiment of Transfected HEK-293T using 98243-1-RR (same clone as 98243-1-PBS)

    1x10^6 HEK-293T cells or Jagged1/CD339 transfected HEK-293T cells were surface stained with 0.25 ug Anti-Human Jagged1 Rabbit Recombinant Antibody (98243-1-RR, Clone:241412A6) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98243-1-PBS in a different storage buffer formulation.

  • FC experiment of Transfected HEK-293T using 98243-1-RR (same clone as 98243-1-PBS)

    FC experiment of Transfected HEK-293T using 98243-1-RR (same clone as 98243-1-PBS)

    1x10^6 HEK-293T cells (left) or Jagged1/CD339 transfected HEK-293T cells (right) were surface stained with 0.25 ug Anti-Human Jagged1/CD339 Rabbit Recombinant Antibody (98243-1-RR, Clone:241412A6) (red) or Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98243-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 98243-1-RR

    Affinity and Kinetic Characterization of 98243-1-RR

    Biolayer interferometry (BLl) kinetic assays of 98243-1-RR against Human Jagged1/CD339 were performed. The affinity constant is 1.57 nM.

产品信息

98243-1-PBS targets Jagged1/CD339 in FC applications and shows reactivity with human samples.

Tested Applications FC Application Description
Tested Reactivity human
Immunogen Recombinant protein 种属同源性预测
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Full Name jagged 1 (Alagille syndrome)
Synonyms Jagged1, JAG1, Protein jagged-1, HJ1, CD339
Calculated Molecular Weight 1218 aa, 134 kDa
GenBank Accession NumberBC098393
Gene Symbol Jagged1
Gene ID (NCBI) 182
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
UNIPROT IDP78504
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Jagged1 (JAG1), also known as CD339, is a type I, membrane-anchored, multi-domain protein and a ligand of the Notch receptor (PMID: 15358557). Jagged1 is composed of a relatively small intracellular domain, a transmembrane domain, and a larger extracellular component containing a cystine-rich region, 16 EGF-like repeats, a DSL domain, and a signal peptide (PMID: 15358557; 26548814). It is widely expressed throughout mammalian development, across many tissues and developmental stages (PMID: 26548814). The Jagged1-NOTCH interaction can trigger the Notch signaling and activate transcription factors that play key roles in cell differentiation and morphogenesis.