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验证数据展示

  • FC experiment of Transfected HEK-293T using 98243-1-RR

    FC experiment of Transfected HEK-293T using 98243-1-RR

    1x10^6 HEK-293T cells or Jagged1/CD339 transfected HEK-293T cells were surface stained with 0.25 ug Anti-Human Jagged1 Rabbit Recombinant Antibody (98243-1-RR, Clone:241412A6) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed.

  • FC experiment of Transfected HEK-293T using 98243-1-RR

    FC experiment of Transfected HEK-293T using 98243-1-RR

    1x10^6 HEK-293T cells (left) or Jagged1/CD339 transfected HEK-293T cells (right) were surface stained with 0.25 ug Anti-Human Jagged1/CD339 Rabbit Recombinant Antibody (98243-1-RR, Clone:241412A6) (red) or Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed.

  • Affinity and Kinetic Characterization of 98243-1-RR

    Affinity and Kinetic Characterization of 98243-1-RR

    Biolayer interferometry (BLl) kinetic assays of 98243-1-RR against Human Jagged1/CD339 were performed. The affinity constant is 1.57 nM.

Anti-Human Jagged1/CD339 Rabbit Recombinant Antibody

Jagged1/CD339 Recombinant Antibody for FC
Cat No. 98243-1-RR

产品说明书

CloneNo. 241412A6

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

FC

别名

Jagged1, JAG1, Protein jagged-1, HJ1, CD339

缓冲液配方:  PBS and Azide
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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经过测试的应用

Positive FC detected inTransfected HEK-293T cells

推荐稀释比

应用推荐稀释比
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

98243-1-RR targets Jagged1/CD339 in FC applications and shows reactivity with human samples.

经测试应用 FC Application Description
经测试反应性 human
免疫原 Recombinant protein 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 jagged 1 (Alagille syndrome)
别名 Jagged1, JAG1, Protein jagged-1, HJ1, CD339
计算分子量 1218 aa, 134 kDa
GenBank蛋白编号BC098393
基因名称 Jagged1
Gene ID (NCBI) 182
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purfication
UNIPROT IDP78504
储存缓冲液 PBS with 0.09% sodium azide , pH 7.3
储存条件Store at 2 - 8°C. Stable for one year after shipment.

背景介绍

Jagged1 (JAG1), also known as CD339, is a type I, membrane-anchored, multi-domain protein and a ligand of the Notch receptor (PMID: 15358557). Jagged1 is composed of a relatively small intracellular domain, a transmembrane domain, and a larger extracellular component containing a cystine-rich region, 16 EGF-like repeats, a DSL domain, and a signal peptide (PMID: 15358557; 26548814). It is widely expressed throughout mammalian development, across many tissues and developmental stages (PMID: 26548814). The Jagged1-NOTCH interaction can trigger the Notch signaling and activate transcription factors that play key roles in cell differentiation and morphogenesis.

实验方案

Product Specific Protocols
FC protocol for Jagged1/CD339 antibody 98243-1-RRDownload protocol
Standard Protocols
Click here to view our Standard Protocols