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  • Featured Product
  • KD/KO Validated

CoraLite® Plus 488-conjugated LRP2-Specific Polyclonal antibody

LRP2-Specific Polyclonal Antibody for IF-P

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

IF-P

Conjugate

CoraLite® Plus 488 Fluorescent Dye

Cat no : CL488-19700

Print datasheet

Synonyms

LRP2, LRP 2, Low-density lipoprotein receptor-related protein 2, gp330, Glycoprotein 330

验证数据展示

  • IF Staining of mouse kidney using CL488-19700

    IF Staining of mouse kidney using CL488-19700

    Immunofluorescent analysis of (4% PFA) fixed paraffin-embedded mouse kidney tissue using CoraLite® Plus 488 LRP2-Specific antibody (CL488-19700) at dilution of 1:200. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

  • IF Staining of mouse kidney using CL488-19700

    IF Staining of mouse kidney using CL488-19700

    Immunofluorescent analysis of (4% PFA) fixed paraffin-embedded mouse kidney tissue using CoraLite® Plus 488 LRP2-Specific antibody (CL488-19700) at dilution of 1:200. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

经过测试的应用

Positive IF-P detected inmouse kidney tissue
Planning an IHC experiment? We recommend our IHCeasy LRP2 Ready-To-Use IHC Kit. LRP2 primary antibody included.
For other applications, we recommend the unconjugated version of this antibody, 19700-1-AP

推荐稀释比

ApplicationDilution
Immunofluorescence (IF)-PIF-P : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

CL488-19700 targets LRP2-Specific in IF-P applications and shows reactivity with human samples.

Tested Applications IF-P Application Description
Tested Reactivity human
Immunogen Peptide 种属同源性预测
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Full Name low density lipoprotein-related protein 2
Synonyms LRP2, LRP 2, Low-density lipoprotein receptor-related protein 2, gp330, Glycoprotein 330
Calculated Molecular Weight 522 kDa
Observed Molecular Weight 280 kDa
GenBank Accession NumberNM_004525
Gene Symbol LRP2
Gene ID (NCBI) 4036
Conjugate CoraLite® Plus 488 Fluorescent Dye
Excitation/Emission Maxima Wavelengths493 nm / 522 nm
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDP98164
Storage Buffer PBS with 50% Glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3.
Storage ConditionsStore at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

LRP2, also named as gp330 and Megalin, belongs to the LDLR family. It acts together with cubilin to mediate HDL endocytosis. LRP2 may participate in regulation of parathyroid-hormone and para-thyroid-hormone-related protein release. Defects in LRP2 are the cause of Donnai-Barrow syndrome (DBS). This antibody is specific to LRP2 and detects endogenous LRP2 with an apparent molecular weight 280 kDa, which is smaller than the predicted molecular weight (522 kDa) and probably represent a proteolytic fragment of the large glycoprotein (PMID: 16638803; 8483924).

实验方案

Product Specific Protocols
IF protocol for CL Plus 488 LRP2-Specific antibody CL488-19700Download protocol
Standard Protocols
Click here to view our Standard Protocols