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验证数据展示

  • IF Staining of mouse kidney using CL488-19700

    IF Staining of mouse kidney using CL488-19700

    Immunofluorescent analysis of (4% PFA) fixed paraffin-embedded mouse kidney tissue using CoraLite® Plus 488 LRP2-Specific antibody (CL488-19700) at dilution of 1:200. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

  • IF Staining of mouse kidney using CL488-19700

    IF Staining of mouse kidney using CL488-19700

    Immunofluorescent analysis of (4% PFA) fixed paraffin-embedded mouse kidney tissue using CoraLite® Plus 488 LRP2-Specific antibody (CL488-19700) at dilution of 1:200. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

  • Featured Product
  • KD/KO验证

CoraLite® Plus 488-conjugated LRP2-Specific Polyclonal antibody

LRP2-Specific Polyclonal Antibody for IF-P
Cat No. CL488-19700

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

IF-P

别名

LRP2, LRP 2, Low-density lipoprotein receptor-related protein 2, gp330, Glycoprotein 330

缓冲液配方:  PBS and Azide
PBS and Azide
偶联物:  CoraLite® Plus 488
规格: 

-/ -

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经过测试的应用

Positive IF-P detected inmouse kidney tissue
Planning an IHC experiment? We recommend our IHCeasy LRP2 Ready-To-Use IHC Kit. LRP2 primary antibody included.
For other applications, we recommend the unconjugated version of this antibody, 19700-1-AP

推荐稀释比

应用推荐稀释比
Immunofluorescence (IF)-PIF-P : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

CL488-19700 targets LRP2-Specific in IF-P applications and shows reactivity with human samples.

经测试应用 IF-P Application Description
经测试反应性 human
免疫原 Peptide 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 low density lipoprotein-related protein 2
别名 LRP2, LRP 2, Low-density lipoprotein receptor-related protein 2, gp330, Glycoprotein 330
计算分子量 522 kDa
观测分子量 280 kDa
GenBank蛋白编号NM_004525
基因名称 LRP2
Gene ID (NCBI) 4036
RRIDAB_3672707
偶联类型 CoraLite® Plus 488 Fluorescent Dye
最大激发/发射波长493 nm / 522 nm
形式 Liquid
纯化方式Antigen affinity purification
UNIPROT IDP98164
储存缓冲液 PBS with 50% glycerol, 0.05% Proclin300, 0.5% BSA , pH 7.3
储存条件Store at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

LRP2, also named as gp330 and Megalin, belongs to the LDLR family. It acts together with cubilin to mediate HDL endocytosis. LRP2 may participate in regulation of parathyroid-hormone and para-thyroid-hormone-related protein release. Defects in LRP2 are the cause of Donnai-Barrow syndrome (DBS). This antibody is specific to LRP2 and detects endogenous LRP2 with an apparent molecular weight 280 kDa, which is smaller than the predicted molecular weight (522 kDa) and probably represent a proteolytic fragment of the large glycoprotein (PMID: 16638803; 8483924).

实验方案

Product Specific Protocols
IF protocol for CL Plus 488 LRP2-Specific antibody CL488-19700Download protocol
Standard Protocols
Click here to view our Standard Protocols