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Lamin B2 Monoclonal antibody, PBS Only

Lamin B2 Monoclonal Antibody for WB, IF/ICC, Indirect ELISA

Host / Isotype

Mouse / IgG1

Reactivity

rat, mouse, human

Applications

WB, IF/ICC, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

2C7B1

Cat no : 68475-1-PBS

Print datasheet

Synonyms

LMNB2, LMN2, Lamin-B2, LAMB2, 2C7B1

验证数据展示

  • WB analysis using 68475-1-Ig (same clone as 68475-1-PBS)

    WB analysis using 68475-1-Ig (same clone as 68475-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 68475-1-Ig (Lamin B2 antibody) at dilution of 1:20000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68475-1-PBS in a different storage buffer formulation.

  • IF Staining of HepG2 using 68475-1-Ig (same clone as 68475-1-PBS)

    IF Staining of HepG2 using 68475-1-Ig (same clone as 68475-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed HepG2 cells using Lamin B2 antibody (68475-1-Ig, Clone: 2C7B1 ) at dilution of 1:1000 and CoraLite®488-Conjugated Goat Anti-Mouse IgG(H+L) (SA00013-1), CL594-phalloidin (red). This data was developed using the same antibody clone with 68475-1-PBS in a different storage buffer formulation.

产品信息

68475-1-PBS targets Lamin B2 in WB, IF/ICC, Indirect ELISA applications and shows reactivity with rat, mouse, human samples.

Tested Applications WB, IF/ICC, Indirect ELISA Application Description
Tested Reactivity rat, mouse, human
Immunogen Lamin B2 fusion protein Ag33296 种属同源性预测
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Full Name lamin B2
Synonyms LMNB2, LMN2, Lamin-B2, LAMB2, 2C7B1
Calculated Molecular Weight 68 kDa
Observed Molecular Weight 68 kDa
GenBank Accession NumberBC006551
Gene Symbol Lamin B2
Gene ID (NCBI) 84823
Conjugate Unconjugated
Form Liquid
Purification MethodProtein G purification
UNIPROT IDQ03252
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Lamins are nuclear membrane structural components that are important in structural integrity of the nucleus and may also interact with chromatin (PMID: 33033404). Research studies show that lamin B2 knockout mice exhibit neuronal developmental defects and that both proteins are essential for typical brain development (PMID: 20145110). Mutations in Lamin B2 can result in a susceptibility to developing acquired partial lipodystrophy, a rare disorder characterized by the progressive loss of subcutaneous fat in a bilaterally symmetrical fashion (PMID: 16826530).