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验证数据展示

  • IHC staining of human colon using 66594-1-Ig (same clone as 66594-1-PBS)

    IHC staining of human colon using 66594-1-Ig (same clone as 66594-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human colon tissue slide using 66594-1-Ig (MAdCAM1 antibody) at dilution of 1:2000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 66594-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with MAdCAM1 antibody included
  • IHC staining of human colon using 66594-1-Ig (same clone as 66594-1-PBS)

    IHC staining of human colon using 66594-1-Ig (same clone as 66594-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human colon tissue slide using 66594-1-Ig (MAdCAM1 antibody) at dilution of 1:2000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 66594-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with MAdCAM1 antibody included
  • IF Staining of human tonsillitis using 66594-1-Ig (same clone as 66594-1-PBS)

    IF Staining of human tonsillitis using 66594-1-Ig (same clone as 66594-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed human tonsillitis tissue using MAdCAM1 antibody (66594-1-Ig, Clone: 2A12E8 ) at dilution of 1:400 and CoraLite®488-Conjugated Goat Anti-Mouse IgG(H+L). This data was developed using the same antibody clone with 66594-1-PBS in a different storage buffer formulation.

  • IF Staining of human tonsillitis using 66594-1-Ig (same clone as 66594-1-PBS)

    IF Staining of human tonsillitis using 66594-1-Ig (same clone as 66594-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed human tonsillitis tissue using MAdCAM1 antibody (66594-1-Ig, Clone: 2A12E8 ) at dilution of 1:400 and CoraLite®488-Conjugated Goat Anti-Mouse IgG(H+L). This data was developed using the same antibody clone with 66594-1-PBS in a different storage buffer formulation.

MAdCAM1 Monoclonal antibody, PBS Only

MAdCAM1 Monoclonal Antibody for IHC, IF-P, Indirect ELISA
Cat No. 66594-1-PBS

产品说明书

CloneNo. 2A12E8

宿主/亚型

Mouse / IgG2a

种属反应性

Human

应用

IHC, IF-P, Indirect ELISA

别名

hMAdCAM 1, MACAM1, MAdCAM 1, MAdCAM1

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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Planning an IHC experiment? We recommend our IHCeasy MAdCAM1 Ready-To-Use IHC Kit. MAdCAM1 primary antibody included.

产品信息

66594-1-PBS targets MAdCAM1 in IHC, IF-P, Indirect ELISA applications and shows reactivity with Human samples.

经测试应用 IHC, IF-P, Indirect ELISA Application Description
经测试反应性 Human
免疫原 MAdCAM1 fusion protein Ag16184 种属同源性预测
宿主/亚型 Mouse / IgG2a
抗体类别 Monoclonal
产品类型 Antibody
全称 mucosal vascular addressin cell adhesion molecule 1
别名 hMAdCAM 1, MACAM1, MAdCAM 1, MAdCAM1
计算分子量 406 aa, 43 kDa
GenBank蛋白编号BC142629
基因名称 MADCAM1
Gene ID (NCBI) 8174
RRIDAB_2881954
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purification
UNIPROT IDQ13477
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Lymphocyte recirculation through different organs is thought to be regulated by adhesion molecules ("homing receptors") recognizing tissue-specific vascular addressins on endothelium (PMID: 7511642). The mucosal vascular addressin, MAdCAM1, is an immunoglobulin superfamily adhesion receptor for lymphocytes that is expressed by mucosal venules and helps direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria (PMID: 7687523). MAdCAM1 can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes.